NCT03173664

Brief Summary

KAMRA inlay, to be unilaterally implanted into the cornea of a subject's non-dominant eye. The inlay is to be inserted into a stromal pocket created with a surgical femtosecond laser.

Trial Health

35
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
529

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jul 2018

Longer than P75 for all trials

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

May 25, 2017

Completed
8 days until next milestone

First Posted

Study publicly available on registry

June 2, 2017

Completed
1.2 years until next milestone

Study Start

First participant enrolled

July 31, 2018

Completed
7.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2026

Completed
Last Updated

May 18, 2018

Status Verified

May 1, 2018

Enrollment Period

7.4 years

First QC Date

May 25, 2017

Last Update Submit

May 17, 2018

Conditions

Outcome Measures

Primary Outcomes (1)

  • Monocular Near Visual Acuity

    Percentage of implanted eyes with monocular near visual acuity of 20/40 or better is greater than or equal to 75% of implanted eyes.

    Five years

Secondary Outcomes (1)

  • Best-corrected distance visual acuity

    Five years

Interventions

Unilateral implantation of the KAMRA inlay in the corneal stroma.

Eligibility Criteria

Age45 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)
Sampling MethodProbability Sample
Study Population

Phakic, presbyopic patients between the ages of 45 and 60 years old who have cycloplegic refractive spherical equivalent of +0.50 diopters to -0.75 diopters with less than or equal to 0.75 diopters of refractive cylinder, who do not require glasses or contact lenses for clear distance vision, and who require near correction of +1.00 to +2.50 diopters of reading add.

You may qualify if:

  • Meet the indications for use for this device;
  • Do not have any of the conditions described in the contraindications in the labeling of the device;
  • Are willing and able to provide informed consent;
  • Are not participating in any other clinical studies during the course of the study.

You may not qualify if:

  • Subject has insufficient ability to read or write that would prevent them from completing a questionnaire without help; or
  • Subject is not a fluent speaker of U.S. English.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Conditions

Presbyopia

Condition Hierarchy (Ancestors)

Refractive ErrorsEye Diseases

Study Officials

  • TBD TBD, M.D.

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Srividhya Vilupuru, O.D., Ph.D

CONTACT

Nicholas Tarantino, O.D.

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 25, 2017

First Posted

June 2, 2017

Study Start

July 31, 2018

Primary Completion

January 1, 2026

Study Completion

January 1, 2026

Last Updated

May 18, 2018

Record last verified: 2018-05

Data Sharing

IPD Sharing
Will not share