NCT03173001|UnknownDMC

Possible Association of Intestinal Helminths and Protozoa With Colorectal Cancer Pathogenesis

Intestinal Helminths and Protozoan Infections in Patients With Colorectal Cancer: Prevalence and Possible Association With Cancer Pathogenesis

Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan ClinicalTrials.gov

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1 other identifier

ADCC 15 21 2

Study Type

observational

Target

500

Locations

0 countries

Sites

N/A

Timeline

RegisteredJun 2017

StartedJan 2015

CompletionDec 2025

Brief Summary

Colorectal cancer (CRC) has the third highest cancer incidence in the world. There is mounting evidence that the intestinal microbiota plays an important role in colorectal carcinogenesis. but there is no information on protozoa of intestinal microbiota except Blastocystis hominis, although data on this issue is scarce. In this study we are going to evaluate the prevalence of intestinal helminthes and protozoa in CRC patients and control group that includes random residents. Patients will be examined before, after surgery and chemotherapy. Parasites and protozoan infection intensity will be estimated by triple coproscopy.

Trial Health

At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date

Enrollment

500

participants targeted

Target at P75+ for all trials

Timeline

Completed

Started Jan 2015

Longer than P75 for all trials

Status

unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

11 years study duration

Study Start

First participant enrolled

January 1, 2015

Completed

2.4 years until next milestone

First Submitted

Initial submission to the registry

May 29, 2017

Completed

3 days until next milestone

First Posted

Study publicly available on registry

June 1, 2017

Completed

8.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2025

Completed

Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2025

Completed

Last Updated

March 3, 2023

Status Verified

March 1, 2023

Enrollment Period

11 years

First QC Date

May 29, 2017

Last Update Submit

March 1, 2023

Conditions

Colorectal Cancer Colorectal Cancer Metastatic Intestinal Parasite Protozoan Infections

Keywords

intestinal helminths; protozoan infections;colorectal cancer; chemotherapy; cancer pathogenesis;

Outcome Measures

Primary Outcomes (3)

Prevalence of intestinal helminths in patients with colorectal cancer and association with cancerogenesis
In this study we expect to find intestinal helminths in patients with colorectal cancer and determine their role in the development of colorectal cancer
from 2015 to 2018 years
Prevalence of Lamblia intestinalis and Cryptosporidium parvum in patients with colorectal cancer and association with cancerogenesis
In this study we expect to find pathogenic protozoa in patients with colorectal cancer and determine their role in the development of colorectal cancer
from 2015 to 2018 years
Prevalence of intestinal protozoa (commensals) in patients with colorectal cancer and association with cancerogenesis
In this study we are going to determine their prevalence and role in the development of colorectal cancer
from 2015 to 2018 years

Study Arms (8)

Patients with colorectal cancer

Patients hospitalized with colorectal cancer at the Department of Coloproctology of Republican Oncology Research Center.