Definition of Hemodynamic Thresholds in Out-of-Hospital Cardiac Arrest

NCT03172468 | Withdrawn

• 1 other identifier: HETOCA-2017-v1.1
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

This study seeks to evaluate, whether patients suffering from cardiac arrest, that can be successfully resuscitated, can be differentiated from those, that cannot be resuscitated, using arterial blood pressure values.

Conditions

Cardiac Arrest

Outcome Measures

Primary Outcomes (1)

• Mean Arterial Blood Pressure

  Mean arterial blood pressure measured invasively via the arterial line.

  immediately after placement of the arterial line

Secondary Outcomes (8)

• Systolic Arterial Blood Pressure

  immediately after placement of the arterial line

• Diastolic Arterial Blood Pressure

  immediately after placement of the arterial line

• Mean Arterial Blood Pressure

  one minute after the first application of epinephrine following placement of the arterial line

• Systolic Arterial Blood Pressure

  one minute after the first application of epinephrine following placement of the arterial line

• Diastolic Arterial Blood Pressure

  one minute after the first application of epinephrine following placement of the arterial line

Study Arms (2)

Survivors

Patients suffering from out-of-hospital cardiac arrest (OHCA), who achieve sustained return of spontaneous circulation (ROSC) following prehospital cardiopulmonary resuscitation.

Non-Survivors

Patients suffering from out-of-hospital cardiac arrest (OHCA), who are declared dead after prehospital cardiopulmonary resuscitation.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adult patients suffering from cardiac arrest on arrival of the physician response unit are to be included, if ALS is deemed reasonable by the emergency physician. The groups to be compared are survivors (patients with sustained return of spontaneous circulation (ROSC) in the field who are transported to a hospital alive) and non-survivors (patients in whom CPR is terminated in the field).

You may qualify if:

• Out-of-hospital cardiac arrest
• Age \>18 years
• Advanced Life Support started
• Arterial line placement possible

You may not qualify if:

• Obvious signs of death
• Advanced Directives / Do Not Attempt Resuscitation Order
• Cardiac arrest of traumatic etiology
• Documented patient refusal in advance

Sponsors & Collaborators

• Medical University of Graz: lead

Study Sites (1)

Prehospital Physician Response System, Medical University of Graz

Graz, Styria, 8036, Austria

Location

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Study Officials

• Paul Zajic, MD

  Div. of General Anaesthesiology, Emergency- and Intensive Care Medicine, Medical University of Graz

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 15, 2017
• First Posted: June 1, 2017
• Study Start: June 7, 2017
• Primary Completion: December 31, 2020
• Study Completion: March 31, 2021
• Last Updated: January 22, 2025

Record last verified: 2025-01

Locations

AU (1)