The Use of Propranolol for the Prevention of Worsening of Esophageal Varices in Patients With Isolated Gastric Varices
Post-balloon Occluded Retrograde Transvenous Obliteration Use of Propranolol for the Prevention of Worsening of Esophageal Varices in Patients With Isolated Gastric Varices
1 other identifier
interventional
74
1 country
1
Brief Summary
Balloon-occluded retrograde transvenous obliteration (BRTO) has been effective method to manage gastric varices. However, more than one third of patients after BRTO treatment experienced worsening of esophageal varices. The present study was designed to evaluate the effect of post-BRTO propranolol adminstration on the change of esophageal varices.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Jun 2017
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 26, 2017
CompletedFirst Posted
Study publicly available on registry
May 31, 2017
CompletedStudy Start
First participant enrolled
June 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 15, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
December 30, 2022
CompletedNovember 23, 2021
November 1, 2021
5 years
May 26, 2017
November 20, 2021
Conditions
Outcome Measures
Primary Outcomes (1)
Worsening of esophageal varices rate
Analysis
3 years
Secondary Outcomes (3)
Variceal rebleeding rate
3 years
Mortality rate
3 years
Worsening of ascites rate
3 years
Study Arms (2)
Propranolol group
EXPERIMENTALPropranolol was given after patients with cirrhosis and isolated gastric varices underwent balloon occluded retrograde transvenous obliteration successfully.
control group
NO INTERVENTIONPropranolol was not given after patients with cirrhosis and isolated gastric varices underwent balloon occluded retrograde transvenous obliteration successfully.
Interventions
Propranolol was given after patients with cirrhosis and isolated gastric varices underwent balloon occluded retrograde transvenous obliteration successfully.
Eligibility Criteria
You may qualify if:
- Clinical diagnosis of liver cirrhosis
- Clinical diagnosis of isolated gastric varices
- The presenec of spontaneous portosystemic shunt
You may not qualify if:
- Contradictions to Propranolol
- Balloon occluded retrograde transvenous obliteration was failed
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
West china Hospital
Chengdu, China
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
xuefeng luo
Sichuan University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Attending doctor
Study Record Dates
First Submitted
May 26, 2017
First Posted
May 31, 2017
Study Start
June 1, 2017
Primary Completion
May 15, 2022
Study Completion
December 30, 2022
Last Updated
November 23, 2021
Record last verified: 2021-11