Blood Flow Index as an Indicator of Successful Peripheral Nerve Block

NCT03169517 | Completed

• 1 other identifier: TJMZK20170325
• Study Type: observational
• Target: 110
• Locations: 1 country
• Sites: 1

Brief Summary

Laser speckle contrast imaging (LSCI) allows real-time, non-invasive, quantitative measurements of regional blood flow. The aim of this prospective observational study was to evaluate the blood flow changes by LSCI after peripheral nerve block and determine whether this novel optical technique can be used as a reliable indicator of successful blocks.

Conditions

Laser

Keywords

Peripheral nerve block; laser speckle contrast imaging; blood flow index

Outcome Measures

Primary Outcomes (1)

• diagnostic power of LSCI and pinprick sensory tests for predicting successful and failed blocks

  sensitivity and specificity

  at 5-min intervals till 30 min after regional block

Secondary Outcomes (1)

• blood flow index

  5 min before regional block and at 5-min intervals till 30 min after regional block

Study Arms (1)

Peripheral nerve block group

patients scheduled for elective upper or lower limb surgery with peripheral nerve block will receive LSCI measurements and pinprick sensory tests at 5 min before the block and at 5-min intervals till 30 min after the block.

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

One hundred adult patients scheduled for elective upper or lower limb surgery with peripheral nerve block

You may qualify if:

• informed consent
• American Society of Anesthesiologists physical statusⅠ-Ⅱ
• Undergo elective upper or lower limb surgery with peripheral nerve block

You may not qualify if:

• refusal to participate in the study
• peripheral vascular disease
• digit injury or deficiency
• colored or infected fingernails/toenails
• BMI\>35
• those who had taken vasodilatory drugs before surgery
• preoperative analgesic medications
• Any contraindications to peripheral nerve block such as coagulation abnormalities, allergy to local anaesthetics, peripheral neuropathy.

Sponsors & Collaborators

• Huazhong University of Science and Technology: lead

Study Sites (1)

Tongji Hospital

Wuhan, Hubei, China

Location

Related Publications (1)

• Wu X, Li J, Joypaul K, Bao WW, Wang D, Huang YJ, Li PC, Mei W. Blood flow index as an indicator of successful sciatic nerve block: a prospective observational study using laser speckle contrast imaging. Br J Anaesth. 2018 Oct;121(4):859-866. doi: 10.1016/j.bja.2018.05.065. Epub 2018 Jul 4.

  PMID: 30236247 DERIVED

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Vice Director, Department of Anaesthesiology, Tongji Hospital of Tongji Medical College

Study Record Dates

• First Submitted: May 24, 2017
• First Posted: May 30, 2017
• Study Start: May 27, 2017
• Primary Completion: September 4, 2017
• Study Completion: September 4, 2017
• Last Updated: September 6, 2017

Record last verified: 2017-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)