Performance in Walking in Osteoarthritis Patients
EX-ART
1 other identifier
interventional
40
1 country
1
Brief Summary
Few data exist to date on the effect of eccentric muscle building in knee osteoarthritis. No studies have compared the effect of eccentric versus concentric reinforcement in knee osteoarthritis. Our study aims to show the effectiveness of an eccentric reinforcement. This is a randomized, interventional trial.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Sep 2017
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 24, 2017
CompletedFirst Posted
Study publicly available on registry
May 30, 2017
CompletedStudy Start
First participant enrolled
September 19, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 25, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
June 17, 2019
CompletedMarch 24, 2026
March 1, 2026
2 months
May 24, 2017
March 20, 2026
Conditions
Outcome Measures
Primary Outcomes (1)
Walking performance
6-minute walk test
after 6 training weeks
Study Arms (2)
concentric work
ACTIVE COMPARATORpatient suffering from knee osteoarthritis will follow a concentric work. This training is 2 sessions per week for 6 weeks
eccentric work
EXPERIMENTALpatient suffering from knee osteoarthritis will follow an eccentric work. This training is 2 sessions per week for 6 weeks
Interventions
patient will follow 2 concentric trainings per week during 6 weeks
Eligibility Criteria
You may qualify if:
- Autonomous subjects aged 40 to 85
- Subjects meeting ACR criteria for gonarthrosis
- Subjects with a score of Kellgren and Lawrence at least one knee greater than or equal to 2
- Signature of consent form
- Subjects affiliated to social security
You may not qualify if:
- Subject with a Kellgren and Lawrence stadium at 4 for at least one of his two knees
- Subjects with symptomatic femoro-patellar arthrosis
- Subject with a pathology that makes walking testing impossible.
- Non-autonomous subjects, with a pathology impairing walking
- Subjects with symptomatic osteoarthritis of the hip and / or with a hip or knee prosthesis
- Subject incapable of signing consent and unable to understand information leaflet.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of rheumatology, nice university hospital
Nice, 06000, France
Related Publications (1)
Trojani MC, Chorin F, Gerus P, Breuil V, Michel C, Guis S, Bendahan D, Roux C. Concentric or eccentric physical activity for patients with symptomatic osteoarthritis of the knee: a randomized prospective study. Ther Adv Musculoskelet Dis. 2022 Jul 7;14:1759720X221102805. doi: 10.1177/1759720X221102805. eCollection 2022.
PMID: 35832351RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Christian H ROUX, PhD
service de Rhumatologie, CHU de NICE
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- OTHER
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 24, 2017
First Posted
May 30, 2017
Study Start
September 19, 2017
Primary Completion
November 25, 2017
Study Completion
June 17, 2019
Last Updated
March 24, 2026
Record last verified: 2026-03