Predictive Value Of Admission Blood Glucose Level In Patients With Acute Myocardial Infarction

NCT03164707 | Unknown

• 1 other identifier: Serum Blood Glucose Level
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

Coronary atherosclerosis is the leading cause of death worldwide. Diabetes mellitus is associated with increased prevalence of coronary artery disease Increased plasma glucose is a common feature in the acute phase of myocardial infarction, even in patients without diabetes. Patients with stress hyperglycemia, but without previous diagnosis of diabetes, were at increased risk of congestive heart failure, arrhythmia and cardiogenic shock as well as increased both in-hospital and long-term mortality . Previous studies have demonstrated larger infarct size and poorer prognosis inpatients with hyperglycemia upon hospital admission compared with patients without hyperglycemia It has been reported that stress hyperglycemia impairs microvascular circulation and may lead to no-reflow phenomenon. No reflow phenomenon was significantly more frequent among patients with hyperglycemia and increased progressively with increasing admission blood glucose in patients with Acute Myocardial Infarction . Furthermore, patients with high admission glucose are more likely to develop restenosis and require repeat revascularization procedures compared with those with normal admission glucose and are also at increased risk for repeated Myocardial Infarction, stent thrombosis and death.

Conditions

Predictive Value of Admission Blood Glucose Level in Acute Myocardial Infarction

Outcome Measures

Primary Outcomes (1)

• Correlation of level of blood glucose on admission in patients with ST Segment Elevation Myocardial Infarction and Hospital Outcome

  1 month

Interventions

Blood Glucose Level DIAGNOSTIC_TEST

ON Admission Blood Glucose Level Fasting Blood Glucose Level

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with Acute ST Segment Elevation Myocardial Infarction admitted in Assiut University Hospital

You may qualify if:

• acute ST Segment Elevation Myocardial Infarction patients not known to have Diabetes Mellitus undergoing primary PCI.

You may not qualify if:

• patients known to have Diabetes mellitus (known diabetes mellitus on admission, which was treated with diet, oral glucose-lowering medication, and/or insulin).
• Patients with prior Primary Percutaneous Intervention and/or Coronary Artery Bypass Graft (altering disease state).
• Patients with severe liver or renal disease (altering disease state).
• Patients with anemia, kidney disease or certain blood disorders (thalassemia).

Sponsors & Collaborators

• Assiut University: lead

Related Publications (5)

• Cura FA, L'Allier PL, Kapadia SR, Houghtaling PL, Dipaola LM, Ellis SG, Topol EJ, Brener SJ; GUSTO IIb and RAPPORT Investigators. Predictors and prognosis of suboptimal coronary blood flow after primary coronary angioplasty in patients with acute myocardial infarction. Am J Cardiol. 2001 Jul 15;88(2):124-8. doi: 10.1016/s0002-9149(01)01605-8.

  PMID: 11448407 RESULT

• Gearhart MM, Parbhoo SK. Hyperglycemia in the critically ill patient. AACN Clin Issues. 2006 Jan-Mar;17(1):50-5. doi: 10.1097/00044067-200601000-00007.

  PMID: 16462409 RESULT

• Iwakura K, Ito H, Ikushima M, Kawano S, Okamura A, Asano K, Kuroda T, Tanaka K, Masuyama T, Hori M, Fujii K. Association between hyperglycemia and the no-reflow phenomenon in patients with acute myocardial infarction. J Am Coll Cardiol. 2003 Jan 1;41(1):1-7. doi: 10.1016/s0735-1097(02)02626-8.

  PMID: 12570936 RESULT

• Mehta RH, Harjai KJ, Cox D, Stone GW, Brodie B, Boura J, O'Neill W, Grines CL; Primary Angioplasty in Myocardial Infarction (PAMI) Investigators. Clinical and angiographic correlates and outcomes of suboptimal coronary flow inpatients with acute myocardial infarction undergoing primary percutaneous coronary intervention. J Am Coll Cardiol. 2003 Nov 19;42(10):1739-46. doi: 10.1016/j.jacc.2003.07.012.

  PMID: 14642681 RESULT

• Rasoul S, Ottervanger JP, Bilo HJ, Timmer JR, van 't Hof AW, Dambrink JH, Dikkeschei LD, Hoorntje JC, de Boer MJ, Zijlstra F. Glucose dysregulation in nondiabetic patients with ST-elevation myocardial infarction: acute and chronic glucose dysregulation in STEMI. Neth J Med. 2007 Mar;65(3):95-100.

  PMID: 17387235 RESULT

Study Officials

• George Motea Doos, M.B.B.CH

  Assiut University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Amr Ahmed Yousef, Professor

CONTACT

01006554042; Amryoussef111@yahoo.com

Heba Mahmoud Elnaggar, Lecturer

CONTACT

01001963100; Heba_m_elnaggar@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 22, 2017
• First Posted: May 24, 2017
• Study Start: December 1, 2017
• Primary Completion: December 1, 2018
• Study Completion: June 1, 2019
• Last Updated: May 24, 2017

Record last verified: 2017-05