UB-421 Combine With Optimized Background Therapy Regimen in Multi-Drug Resistant HIV-1 Infection Patients

NCT03164447 | Unknown Phase 2 FDA Drug

• 1 other identifier: UBP-A205-HIV
• Study Type: interventional
• Target: 10
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is a Phase 2, multi-center study, designed to evaluate the efficacy, safety, and tolerability of UB-421 in conjunction with a failing existing ART regimen for 1 week and optimized background therapy (OBT) for 24 weeks, respectively.

Conditions

HIV-1 Infection

Outcome Measures

Primary Outcomes (1)

• Effectiveness by Viral Load Log10 Change from Baseline

  2 weeks

Secondary Outcomes (3)

• Number of participants with treatment-related adverse events

  35 weeks

• Peak concentration of UB-421

  35 weeks

• Trough concentration of UB-421

  35 weeks

Study Arms (1)

Multi-Drug Resistant

EXPERIMENTAL

Biological: UB-421; Drug: Optimized background therapy (OBT)

Interventions

UB-421 BIOLOGICAL

Monoclonal antibody by IV infusion

Multi-Drug Resistant

Optimized background therapy (OBT) DRUG

The prescribed OBT must contain at least one agent to which the participant's virus is known to be fully sensitive.

Multi-Drug Resistant

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Males and females, age ≥18 years;
• HIV-1 seropositive, with documented HIV-1 infection by official, signed, written history (eg. Laboratory report);
• Receiving a combination antiretroviral therapy (cART) (failing regimen) for at least 8 weeks before Screening and are willing to continue on the failing regimen during the Screening Phase and up to Day 14 of the Treatment Phase, OR have failed in the past 8 weeks of Screening and are off therapy and are willing to stay off therapy until Day 14 of the Treatment Phase;
• Plasma HIV-1 RNA ≥ 1000 copies/mL at the Screening Visit and documented detectable viral load (HIV-1 RNA \>200 copies/ml) within the last 3 months prior to the Screening Visit;
• Highly treatment-experienced HIV-infected patients with documented genotypic and/or phenotypic resistance to at least one ARV drug within three or more drug classes of antiretroviral medications and have difficulty in constructing a viable suppressive regimen.
• Have full viral sensitivity/susceptibility to at least one approved antiretroviral agent, other than UB-421, as determined by genotypic and/or phenotypic ARV drug resistance tests at screening, and such agent can be used as a component of OBT;
• Be willing to remain on treatment without any changes or additions to the OBT regimen, except for toxicity management or upon meeting criteria for treatment failure;
• Have a life expectancy that is \> 9 months;
• Laboratory values at Screening of:
• Absolute neutrophil count (ANC) ≥ 750/mm3;
• Hemoglobin (Hb) ≥ 10.5 gm/dL (male) or ≥ 9.5 gm/dL (female);
• Platelets ≥ 75,000 /mm3;
• Serum alanine transaminase (SGPT/ALT) \< 2.5 x upper limit of normal (ULN);
• Serum aspartate transaminase (SGOT/AST) \< 2.5 x ULN;
• Bilirubin (total) \< 2.5 x ULN unless Gilbert's disease is present or subject is receiving atazanavir in the absence of other evidence of significant liver disease; and

You may not qualify if:

• Any currently active AIDS-defining illness per Category C conditions according to the Center for Disease Control (CDC) Classification System for HIV Infection, with the following exceptions: local cutaneous Kaposi's sarcoma, wasting syndrome due to HIV or any other AIDS-defining illness for which no therapeutic treatment is required OR the required treatment is not included in the list of prohibited medications;
• Subjects with baseline liver disease including active Hepatitis B or C infection or any other active infection secondary to HIV requiring acute therapy;
• Subjects with baseline CD4 counts \< 350 cells/mm\^3.
• Any ≥ Grade 3 laboratory abnormality according to the division of AIDS grading scale;
• Unexplained fever or clinically significant illness within 2 weeks prior to the first dose of study drug;
• Any vaccination within 2 weeks prior to the first dose of study drug;
• Any immunomodulating therapy (excluding pre-medication steroid) or systemic chemotherapy within 4 weeks prior to the Screening Visit;
• Any radiation therapy within 4 weeks prior to the Screening Visit;
• Any previous exposure to monoclonal antibody for the treatment of HIV within 12 weeks prior to the Screening Visit (excluding ibalizumab);
• Participation in an experimental drug trial(s) within 4 weeks prior to the Screening Visit;
• Any prior exposure to UB-421;
• Females who are pregnant, lactating, or breastfeeding, or who plan to become pregnant during the study; and
• Any significant diseases (other than HIV-1 infection) or clinically significant findings that, in the Investigator's judgment, would potentially compromise study compliance or the ability to evaluate safety/efficacy.

Sponsors & Collaborators

• United BioPharma: lead

MeSH Terms

Interventions

UB-421

Central Study Contacts

Zhonghao Shi

CONTACT

+886-3-668-4800; Zhonghao.Shi@unitedbiopharma.com

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 21, 2017
• First Posted: May 23, 2017
• Study Start: December 1, 2023
• Primary Completion: March 1, 2024
• Study Completion: May 1, 2024
• Last Updated: April 24, 2023

Record last verified: 2022-05