Aerobic Treadmill Exercise And Metabolism

NCT03162991 | Completed

• 1 other identifier: Pro00067271
• Study Type: interventional
• Target: 8
• Locations: 1 country
• Sites: 1

Brief Summary

Overview- In this study, overweight or obese, sedentary participants (age=35-55 years, n=20) will be randomized to a 12-week control period or an aerobic exercise intervention. Those randomized into the control group will then complete the exercise intervention subsequently. The planned energy expenditure per week of exercise will be 10-12 kilocalories per kilogram of body weight per week. Participants will complete three non-consecutive exercise sessions per week. Body weight, resting metabolic rate via indirect calorimetry, peak oxygen consumption (VO2peak) through graded exercise testing, fasting blood samples, CGM, sleep and dietary habits via self-report, and physical activity monitoring will be completed at prior to and following the aerobic exercise intervention.

Conditions

Metabolism Disorder, Glucose; Physical Activity; Sedentary Lifestyle

Outcome Measures

Primary Outcomes (2)

• Continuous Glucose Monitoring

  Fasting, Postprandial, and Matched Time Point Glucose Measurements

  3-6 months

• Glucose Regulatory Hormones

  Fasting blood concentrations of Glucose Regulatory Hormones

  3-6 months

Study Arms (2)

12-Week Aerobic Exercise Intervention

EXPERIMENTAL

Other: Aerobic Exercise Intervention

12-Week Control Period

NO INTERVENTION

Interventions

Aerobic Exercise Intervention OTHER

Aerobic Exercise Intervention- 12-weeks, exercise 3 non-consecutive days/week for \~30-55 minutes per exercise session.

12-Week Aerobic Exercise Intervention

Eligibility Criteria

• Age: 35 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• be age 35-55 years of age,
• have 25≤body mass index (BMI)≤40 kg/m2,
• be weight stable (±2%) during the previous 3 months,
• have ˂120 minutes of resistance or endurance exercise per week during the previous 3 months, and
• for females, be eumenorrheic, or post-menopausal for ≥1 year.

You may not qualify if:

• self-reported medical conditions (e.g. diabetes), cardiovascular diseases, chronic or recurrent respiratory conditions (e.g. uncontrolled asthma or chronic obstructive pulmonary disease), active cancer, and eating, or neurological disorders,
• medications that affect metabolism (e.g. thyroid medications, statins),
• psychological issues, including but not limited to untreated depression and attention deficit disorder,
• excessive caffeine use (\>500 mg/day),
• smoking during the past year,
• pregnant or lactating females,
• unwillingness to provide informed consent.

Sponsors & Collaborators

• University of South Carolina: lead

Study Sites (1)

Public Health Research Center

Columbia, South Carolina, 29208, United States

Location

MeSH Terms

Conditions

Glucose Metabolism Disorders; Motor Activity; Sedentary Behavior

Condition Hierarchy (Ancestors)

Metabolic Diseases; Nutritional and Metabolic Diseases; Behavior

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD Candidate; Graduate/Research Assistant

Study Record Dates

• First Submitted: May 19, 2017
• First Posted: May 22, 2017
• Study Start: November 13, 2017
• Primary Completion: April 15, 2019
• Study Completion: April 15, 2019
• Last Updated: April 18, 2019

Record last verified: 2019-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)