Preoperative Anxiety's Incidence and Related Factors in Surgical Patients

NCT03162692 | Unknown

• 1 other identifier: XYFY2017-KL021-01
• Study Type: observational
• Target: 2,000
• Locations: 1 country
• Sites: 1

Brief Summary

Preoperative anxiety is often described as an uncomfortable, tense unpleasant mood before surgery, an emotional response to a potential challenge or threat to reality. Data show that adult patients with preoperative anxiety rate of 30-40%. The main reason for the occurrence of patients for surgery, anesthesia and other factors of fear. Preoperative anxiety itself is not a mental illness, but studies have confirmed that the occurrence of preoperative anxiety and postoperative complications were positively correlated, and the existence of preoperative anxiety in patients with conventional postoperative analgesic effect is poor. At present, there are still few studies on the relationship between preoperative anxiety and postoperative complications and analgesia. At the same time, there is a lack of large sample size to study the incidence of preoperative anxiety and its related predictors.

Conditions

Elective Surgery; Intravenous Anesthesia; Preoperative Anxiety

Outcome Measures

Primary Outcomes (1)

• Anxiety level

  as measured by STAI (state-trait anxiety questionnaire)

  All patients are evaluated one day before surgery

Secondary Outcomes (1)

• VAS pain score

  at 3 hours, 6 hours, 24 hours, 48 hours after surgery

Other Outcomes (1)

• blood inflammation index

  Extraction of arterial blood before anesthesia induction

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

2000 patients undergoing elective general anesthesia in surgery in Xuzhou Medical University patients.

You may qualify if:

• Age 18-70 years old
• Sign that informed consent is willing to participate in the study
• Education: primary school and above
• days after elective general anesthesia surgery
• ASA score grade I-III

You may not qualify if:

• Emergency surgery
• Severe mental illness patients (such as anxiety, depression, schizophrenia, etc.)
• Taking anti-anxiety or antidepressants (benzodiazepines, tricyclic antidepressants, selective serotonin inhibitors, monoamine oxidase inhibitors, etc.)

Sponsors & Collaborators

• Xuzhou Medical University: lead

Study Sites (1)

The Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, 221000, China

RECRUITING

Related Publications (9)

• Lieb K, Fiebich BL, Berger M. [Substance P receptor antagonists--a new antidepressive and anxiolytic mechanism?]. Nervenarzt. 2000 Sep;71(9):758-61. doi: 10.1007/s001150050661. German.

  PMID: 11042872 RESULT

• Maki Y. [A behavioral and neurochemical study on the mechanism of the anxiolytic effect of monoamine oxidase inhibitors]. Hokkaido Igaku Zasshi. 2001 May;76(3):133-42. Japanese.

  PMID: 11481866 RESULT

• Yamauchi M, Hiraoka S, Imanishi T. [Role of the serotonergic nervous system in anxiety disorders and the anxiolytic mechanism of selective serotonin reuptake inhibitors]. Nihon Shinkei Seishin Yakurigaku Zasshi. 2006 Nov;26(5-6):193-8. Japanese.

  PMID: 17240844 RESULT

• Matsumoto K, Puia G, Dong E, Pinna G. GABA(A) receptor neurotransmission dysfunction in a mouse model of social isolation-induced stress: possible insights into a non-serotonergic mechanism of action of SSRIs in mood and anxiety disorders. Stress. 2007 Mar;10(1):3-12. doi: 10.1080/10253890701200997.

  PMID: 17454962 RESULT

• Herrera-Ruiz M, Gonzalez-Carranza A, Zamilpa A, Jimenez-Ferrer E, Huerta-Reyes M, Navarro-Garcia VM. The standardized extract of Loeselia mexicana possesses anxiolytic activity through the gamma-amino butyric acid mechanism. J Ethnopharmacol. 2011 Nov 18;138(2):261-7. doi: 10.1016/j.jep.2011.09.010. Epub 2011 Sep 16.

  PMID: 21979412 RESULT

• Mico JA, Prieto R. Elucidating the mechanism of action of pregabalin: alpha(2)delta as a therapeutic target in anxiety. CNS Drugs. 2012 Aug 1;26(8):637-48. doi: 10.2165/11634510-000000000-00000.

  PMID: 22784017 RESULT

• O'Donovan A, Slavich GM, Epel ES, Neylan TC. Exaggerated neurobiological sensitivity to threat as a mechanism linking anxiety with increased risk for diseases of aging. Neurosci Biobehav Rev. 2013 Jan;37(1):96-108. doi: 10.1016/j.neubiorev.2012.10.013. Epub 2012 Nov 2.

  PMID: 23127296 RESULT

• Fan JM, Chen XQ, Du JZ. Prenatal stress, anxiety and depression: a mechanism involving CRH peptide family. Neuro Endocrinol Lett. 2014;35(6):429-39.

  PMID: 25433848 RESULT

• He W, Zhou Q, Yu S, Cai D, Wang Q, Zhang X, Huang WQ. [Mechanism on atrial natriuretic peptide receptor in anti-anxiety with acupuncture based on its tranquilizing effect]. Zhongguo Zhen Jiu. 2015 Jan;35(1):101-4. Chinese.

  PMID: 25906584 RESULT

Study Officials

• Jindong Liu, M.S

  The Affiliated Hospital of Xuzhou Medical University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Jindong Liu, M.S

CONTACT

+86-13951355136; liujindong1818@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief physician and Associate Professor

Study Record Dates

• First Submitted: May 18, 2017
• First Posted: May 22, 2017
• Study Start: April 1, 2017
• Primary Completion: February 1, 2018
• Study Completion: February 1, 2018
• Last Updated: May 22, 2017

Record last verified: 2017-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)