Evaluation of Nutritional Status in Thalassemia Major Patients in Assiut Children Hospital

NCT03161899 | Completed

• 1 other identifier: ENST
• Study Type: observational
• Target: 246
• Locations: 1 country
• Sites: 1

Brief Summary

Thalassemia is a blood disorder passed down through families in which the body makes an abnormal form of hemoglobin. There are 2 main types of thalassemia; Alpha \& Beta thalassemia. Alpha thalassemia: occurs when a gene or genes related to the alpha globin protein are missing or mutated. Beta-thalassemia syndromes are a group of hereditary blood disorders characterized by reduced or absent beta globin chain synthesis. Beta-thalassemias can be classified into: Silent carrier: completely asymptomatic with normal hematological parameters. Beta-thalassaemia minor (beta-thalassaemia trait): usually asymptomatic; diagnosis is made during a work-up for mild anemia. Beta-thalassaemia intermedia: usually a similar presentation to beta-thalassaemia major; symptoms are usually less pronounced and the course is usually more insidious. Beta-thalassaemia major : In which there is complete absence of hemoglobin A

Conditions

Thalassemia Major

Keywords

thalassemia - nutrition -growth

Outcome Measures

Primary Outcomes (1)

• percentage of malnutrition

  prevalence of malnutrition among thalassemic children attending assiut university children hospital

  12 month

Secondary Outcomes (2)

• aetiology poor growth

  12 month

• decrease morbidity

  18 month

Eligibility Criteria

• Age: 6 Years - 14 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

all beta thalassemic patients attending the children Hematology Clinic, Children Hospital, Assiut University, during the period of 1st of June 2017 till 31 th of may 2018.

You may qualify if:

• patients diagnosed to have thalassemia

You may not qualify if:

• patient with any underlaying systemic diseases other than B thalassemia major.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Asmaa Refaat Abdelmonem

Asyut, Egypt

Location

Related Publications (3)

• Soliman AT, El-Matary W, Fattah MM, Nasr IS, El Alaily RK, Thabet MA. The effect of high-calorie diet on nutritional parameters of children with beta-thalassaemia major. Clin Nutr. 2004 Oct;23(5):1153-8. doi: 10.1016/j.clnu.2004.03.001.

  PMID: 15380908 BACKGROUND

• Fung EB. Nutritional deficiencies in patients with thalassemia. Ann N Y Acad Sci. 2010 Aug;1202:188-96. doi: 10.1111/j.1749-6632.2010.05578.x.

  PMID: 20712792 BACKGROUND

• Galanello R, Origa R. Beta-thalassemia. Orphanet J Rare Dis. 2010 May 21;5:11. doi: 10.1186/1750-1172-5-11.

  PMID: 20492708 BACKGROUND

MeSH Terms

Conditions

beta-Thalassemia

Condition Hierarchy (Ancestors)

Thalassemia; Anemia, Hemolytic, Congenital; Anemia, Hemolytic; Anemia; Hematologic Diseases; Hemic and Lymphatic Diseases; Hemoglobinopathies; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Study Officials

• asmaa refaat, MBBCH

  Assuit , faculty of medicine, egypt

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident doctor of pediatrics

Study Record Dates

• First Submitted: May 19, 2017
• First Posted: May 22, 2017
• Study Start: December 15, 2018
• Primary Completion: May 24, 2020
• Study Completion: July 20, 2020
• Last Updated: July 30, 2020

Record last verified: 2020-07

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)