Blood Pressure Target in Acute Stroke to Reduce hemorrhaGe After Endovascular Therapy
BP-TARGET
Comparison of Two Strategies for Blood Pressure Control in the Setting of Acute Ischemic Stroke to Reduce Cerebral Hemorrhage After Thrombectomy: Systolic Blood Pressure Target of Less Than 130 mmHg vs Less Than 185 mmHg, for 24 Hours Following Reperfusion, in Patients With Cerebral Infarction Due to Occlusion of the Anterior Circulation
1 other identifier
interventional
320
1 country
7
Brief Summary
A randomized, multicenter study comparing two strategies: 1 / standard management of systolic blood pressure according to international recommendations (systolic blood pressure \<185 mm Hg) versus 2 / intensive blood pressure management Systolic with a target \<130 mm Hg.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Jun 2017
Typical duration for not_applicable
7 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 18, 2017
CompletedFirst Posted
Study publicly available on registry
May 19, 2017
CompletedStudy Start
First participant enrolled
June 21, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
January 31, 2020
CompletedAugust 3, 2021
August 1, 2021
2.5 years
May 18, 2017
August 2, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Rate of patients with intracranial hemorrhagic complications
Rate of patients with intracranial hemorrhagic complications (Symptomatic or asymptomatic) on cerebral scan, evaluated with a double centralized blind reading
Scan performed between 24 and 36 hours after thrombectomy
Study Arms (2)
Intensive blood pressure management
EXPERIMENTALStandard blood pressure management
ACTIVE COMPARATORInterventions
Adaptation of antihypertensive treatments to reach the Systolic blood pressure target \< 130 mm Hg
Adaptation of antihypertensive treatments to reach the Systolic blood pressure target \< 185 mm Hg
Eligibility Criteria
You may qualify if:
- Intracranial Occlusion of internal carotid arteries and/or proximal middle cerebral (segment M1) diagnosis made on initial Imaging.
- Reperfusion after a thrombectomy procedure (defined by a 2b-3 TICI score -Thrombolysis In Cerebral Infarction- score).
You may not qualify if:
- Per-procedure hemorrhagic complications (prior to reperfusion)
- Systolic blood pressure at baseline \<130 mm Hg within one hour of recanalization
- Pre-existing stroke handicap defined by a Rankin score (modified scale, mRS)\> 3
- Hemodynamically significant carotid stenosis
- Occlusion of the isolated cervical carotid artery
- Known pregnancy
- Legal protection
- Non-affiliation to a social security scheme
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (7)
CHU de Bordeaux
Bordeaux, France
Hôpital neurologique Pierre Wertheimer, Hospices Civils de Lyon
Lyon, France
Centre Hospitalier Régional Universitaire
Nancy, France
Hopital Lariboisière
Paris, 75010, France
Fondation Ophtalmologique A de Rothschild
Paris, 75019, France
Hopital Foch
Suresnes, France
Hopital de purpan
Toulouse, 31 100, France
Related Publications (4)
Maier B, Brauner R, Escalard S, Gory B, Lapergue B, Sibon I, Richard S, Labreuche J, Kyheng M, Desilles JP, Blanc R, Piotin M, Halimi JM, Mazighi M; BP-TARGET Trial Investigators. Association of Contrast Enhancement After Reperfusion With Outcomes According to Blood Pressure Lowering in Patients With Acute Ischemic Stroke. Neurology. 2022 Nov 22;99(21):e2385-e2394. doi: 10.1212/WNL.0000000000201173. Epub 2022 Aug 30.
PMID: 36041869DERIVEDMaier B, Gory B, Lapergue B, Sibon I, Richard S, Kyheng M, Labreuche J, Desilles JP, Blanc R, Piotin M, Mazighi M, Halimi JM; BP TARGET Investigators. Effect of Baseline Antihypertensive Treatments on Stroke Severity and Outcomes in the BP TARGET Trial. Stroke. 2022 Jun;53(6):1837-1846. doi: 10.1161/STROKEAHA.121.037548. Epub 2022 Mar 24.
PMID: 35321558DERIVEDAnadani M, Maier B, Escalard S, Labreuche J, de Havenon A, Sabben C, Lapergue B, Gory B, Richard S, Sibon I, Desilles JP, Blanc R, Piotin M, Mazighi M; of behalf the BP-TARGET Study Group*. Magnitude of Blood Pressure Change After Endovascular Therapy and Outcomes: Insight From the BP-TARGET Trial. Stroke. 2022 Mar;53(3):719-727. doi: 10.1161/STROKEAHA.121.036701. Epub 2022 Feb 3.
PMID: 35109685DERIVEDMazighi M, Richard S, Lapergue B, Sibon I, Gory B, Berge J, Consoli A, Labreuche J, Olivot JM, Broderick J, Duhamel A, Touze E, Qureshi AI, Yavchitz A, Escalard S, Desilles JP, Redjem H, Smajda S, Fahed R, Hebert S, Maier B, Delvoye F, Boursin P, Maacha MB, Obadia M, Sabben C, Blanc R, Savatovsky J, Piotin M; BP-TARGET investigators. Safety and efficacy of intensive blood pressure lowering after successful endovascular therapy in acute ischaemic stroke (BP-TARGET): a multicentre, open-label, randomised controlled trial. Lancet Neurol. 2021 Apr;20(4):265-274. doi: 10.1016/S1474-4422(20)30483-X. Epub 2021 Feb 26.
PMID: 33647246DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Mikael MAZIGHI, MD PhD
Fondation Ophtalmologique A. de Rothschild
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- NETWORK
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 18, 2017
First Posted
May 19, 2017
Study Start
June 21, 2017
Primary Completion
December 31, 2019
Study Completion
January 31, 2020
Last Updated
August 3, 2021
Record last verified: 2021-08