Transcriptome Study of Acute Myocardial Infarction

NCT03158597 | Unknown

• 1 other identifier: 5172011
• Study Type: observational
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare whole-blood microarray gene-expression profiling between patients with acute myocardial infarction and normal participants without cardiovascular diseases. Firstly, screening differentially genes of mRNA to perform gene ontology and pathway analysis. Secondly, predicting target genes regulated by microRNA and constructing coexpression network with mRNA. Thirdly, biological function experiment of microRNA. Finally, revealing pathogenic mechanisms associated with acute myocardial infarction.

Conditions

Acute Myocardial Infarction

Outcome Measures

Primary Outcomes (1)

• Number of screening differentially expressed genes associated with acute myocardial infarction as measured by microarray

  up to 3 years

Study Arms (2)

AMI

Control

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

AMI patients will be selected from Emergency Department of Beijing An Zhen Hospital or Beijing Tong Ren Hospital. Normal control participants will be recruited from Health Examination Center of Beijing An Zhen Hospital.

You may qualify if:

• AMI patients:
• years of age
• Symptoms of ischaemia
• New significant ST-segment-T wave changes in ECG and definitive diagnosis of non-ST elevation MI or ST elevation MI
• Cardiac troponin with at least one value above the 99th percentile upper reference limit
• Normal control participants:
• years of age
• Normal ECG
• BMI \<24kg/m2
• systolic blood pressure \<140mmHg
• diastolic blood pressure \<90mmHg
• Total cholesterol \<200mg/dl (5.18mmol/L)
• Triglyceride \<150mg/dl (1.70mmol/L)
• High density lipoprotein cholesterol \>=40mg/dl (1.04mmol/L)
• Low density lipoprotein cholesterol \<130mg/dl (3.37mmol/L)

You may not qualify if:

• Cardiac death with symptoms suggestive of myocardial ischaemia and presumed new ischaemic ECG changes, but death occurred before cardiac biomarkers were obtained, or before cardiac biomarker values would be increased
• Prior myocardial infarction
• Percutaneous coronary intervention related MI
• Stent thrombosis associated with MI
• Coronary artery bypass grafting related MI
• Recurrent MI or reinfarction
• Myocardial injury with necrosis caused by transcatheter aortic valve implantation or mitral clip or ablation of arrhythmias
• Myocardial injury or infarction associated with heart failure
• Myocardial infarction in the intensive care unit
• Other diseases: previous history of ASCVD, cancer, rheumatoid arthritis, liver or kidney disease, myeloproliferative disorders, chronic inflammation, peripheral vascular disease
• Not available informed consent

Sponsors & Collaborators

• Beijing Institute of Heart, Lung and Blood Vessel Diseases: lead

Study Sites (1)

Beijing Anzhen Hospital

Beijing, Chaoyang, 100029, China

RECRUITING

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 15, 2017
• First Posted: May 18, 2017
• Study Start: June 1, 2017
• Primary Completion: December 31, 2019
• Study Completion: December 31, 2019
• Last Updated: July 14, 2017

Record last verified: 2017-07

Locations

CN (1)