NCT03151850|Unknown
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Sponsor study identifier
observational
50
1 country
1
Study Start
July 2016
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
August 2017
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
August 2017
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
We analyzed the diversity of the fungal and bacterial within colon mucosa between patients with different degree of inflammation of Ulcerative Colitis.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 2017
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 2016
Date type not reportedThis date has not been verified as actual or estimated.
December 19, 2016
Actual (reported)May 12, 2017
Actual (reported)August 2017
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
August 2017
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
fungus detection rate
Fungi detection rate was defined as the percentage of patients in whose colonic mucosa at least one kind of fungus were identified.
6 months
yeasts detection rate
Yeasts detection rate was defined as the percentage of patients in whose colonic mucosa yeasts were identified.
6 months
candida albicans detection rate
Candida albicans detection rate was defined as the percentage of patients in whose colonic mucosa candida albicans were identified.
6 months
We analysed the diversity of the fungal and bacterial in patients with Ulcerative Colitis (UC). We take 2 pieces of biopsies in the sigmoid colon mucosa inflammation area during the colonoscopy and then perform gene sequencing.
Analysing the diversity of the fungal and bacterial in patients without ulcerative colitis. We take 2 pieces of biopsies in the sigmoid colon mucosa during the colonoscopy and then perform gene sequencing.
We take 2 pieces of biopsies in the sigmoid colon mucosa inflammation area during the colonoscopy and then perform gene sequencing.
We take 2 pieces of biopsies in the sigmoid colon mucosa during the colonoscopy and then perform gene sequencing.
Consecutive patients under endoscopic surveillance or examination at Qilu Hospital were considered for inclusion.
Qilu Hospital, Shandong University
Jinan, Shandong, 250012, China
Sokol H, Leducq V, Aschard H, Pham HP, Jegou S, Landman C, Cohen D, Liguori G, Bourrier A, Nion-Larmurier I, Cosnes J, Seksik P, Langella P, Skurnik D, Richard ML, Beaugerie L. Fungal microbiota dysbiosis in IBD. Gut. 2017 Jun;66(6):1039-1048. doi: 10.1136/gutjnl-2015-310746. Epub 2016 Feb 3.
Mukhopadhya I, Hansen R, Meharg C, Thomson JM, Russell RK, Berry SH, El-Omar EM, Hold GL. The fungal microbiota of de-novo paediatric inflammatory bowel disease. Microbes Infect. 2015 Apr;17(4):304-10. doi: 10.1016/j.micinf.2014.12.001. Epub 2014 Dec 15.
Xiuli Zuo, PhD
Qilu Hospital of Shandong University
First Submitted
December 19, 2016
First Posted
May 12, 2017
Study Start
July 2016
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
August 2017
Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Active Ulcerative Colitis
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Eriksson M, Johannssen T, von Smolinski D, Gruber AD, Seeberger PH, Lepenies B. The C-Type Lectin Receptor SIGNR3 Binds to Fungi Present in Commensal Microbiota and Influences Immune Regulation in Experimental Colitis. Front Immunol. 2013 Jul 16;4:196. doi: 10.3389/fimmu.2013.00196. eCollection 2013.
Shang Y, Wang X, Diao X, Li L, Zuo X. The Degree of Mucosa-Associated Microecological Imbalance in Ulcerative Colitis Patients with Different Mayo Score and Its Relationship with Mucosal Mechanical Barrier Damage. Turk J Gastroenterol. 2025 Oct 9;37(1):26-34. doi: 10.5152/tjg.2025.24609.
This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
August 2017
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
May 12, 2017
Record last verified: 2017-05
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