Study Stopped
IRB expired
Evaluating MMPs in Burns
Evaluating a Point-of-Care, Quantitative Matrix Metalloproteinase Assay as a Predictor of Successful Graft Take in Patients Undergoing Cutaneous Auto Grafting for Acute Burn Injury- A Pilot Study
1 other identifier
observational
8
1 country
2
Brief Summary
The objective of this study is to determine whether our chemical assay can be used to reliably predict graft take or failure in patients undergoing autologous skin grafting for treatment of acute burn injury.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Jun 2017
Typical duration for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 9, 2017
CompletedFirst Posted
Study publicly available on registry
May 11, 2017
CompletedStudy Start
First participant enrolled
June 9, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 8, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 8, 2020
CompletedMarch 26, 2021
March 1, 2021
3.5 years
May 9, 2017
March 23, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Predictability of graft take
Determine whether chemical assay can be used to reliably predict graft take or failure in patients undergoing autologous skin grafting for treatment of acute burn injury.
2 years
Secondary Outcomes (1)
Wound healing
2 years
Study Arms (1)
Patients admitted to the burn center
Patients admitted to the Burn Service with acute burn injuries requiring at least one surgical excision and grafting operation.
Interventions
Autogenous skin grafting is the only definitive treatment for the full thickness burn injuries, and thus represents the centerpiece of modern burn care.
Eligibility Criteria
Adult burn patients admitted
You may qualify if:
- years of age or older
- Burn injury less than one week old
You may not qualify if:
- Electrical, chemical or cold-induced burn injury
- Total body surface area burn \>50 %
- Patients not expected to survive
- Patients presenting with re-injury to previously burned and treated areas.
- Patients who present after receiving burn excision surgery out an outside facility for the current acute injury
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
UF Health Cancer Hospital
Gainesville, Florida, 32608, United States
UF Health Shands at the University of Florida
Gainesville, Florida, 32610, United States
Related Publications (1)
Weigelt MA, Lev-Tov HA, Tomic-Canic M, Lee WD, Williams R, Strasfeld D, Kirsner RS, Herman IM. Advanced Wound Diagnostics: Toward Transforming Wound Care into Precision Medicine. Adv Wound Care (New Rochelle). 2022 Jun;11(6):330-359. doi: 10.1089/wound.2020.1319. Epub 2021 Jul 21.
PMID: 34128387DERIVED
Biospecimen
Acute burn wound exudate Acute burn wound tissue
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Joshua S. Carson, MD
University of Florida
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 9, 2017
First Posted
May 11, 2017
Study Start
June 9, 2017
Primary Completion
December 8, 2020
Study Completion
December 8, 2020
Last Updated
March 26, 2021
Record last verified: 2021-03
Data Sharing
- IPD Sharing
- Will not share