Effect of NLR and MPV on Early Postoperative Outcome in Lower Extremity Arthroplasty Operations

NCT03148951 | Completed

• 1 other identifier: MANLOP
• Study Type: observational
• Target: 754
• Locations: 1 country
• Sites: 1

Brief Summary

In the planned study the investigators want to evaluate the relation between postoperative complications and minor/ major morbidities, mortality and Mean Platelet Volume (MPV) and Neutrophil/ lymphocyte (N/L) ratio.

Conditions

Knee Arthropathy

Keywords

MPV; NLR; Postoperative pain

Outcome Measures

Primary Outcomes (1)

• postoperative VAS (visual analogue scale) score

  postoperative visual analog scale score for pain evaluation 0,10,20,30,40,50,60,70,80,90,100)

  VAS score at postoperative twenty-forth hours will be evaluated

Secondary Outcomes (2)

• analgesic drugs

  total dose of analgesic drugs required at twenty four hours will be evaluated

• postoperative major morbidities

  at postoperative first, sixth, twelfth and twenty-forth hours

Other Outcomes (1)

• postoperative side effects

  at postoperative first, sixth, twelfth and twenty-forth hours

Study Arms (4)

Group 1

Group 1: patients receiving general anesthesia and having a postoperative pain VAS score equal to or below 50 at 1st, 6th, 12th nd 24th hours the pain sores will be evaluated at 4 time intervals and so the number of patients in every group may change at every time interval.

Group 2

Group 2: patients receiving general anesthesia and having a postoperative pain VAS score equal to or above 60 at 1st, 6th, 12th nd 24th hours the pain sores will be evaluated at 4 time intervals and so the number of patients in every group may change at every time interval.

Group 3

Group 3: patients receiving regional (spinal) anesthesia and having a postoperative pain VAS score equal to or below 50 at 1st, 6th, 12th nd 24th hours the pain sores will be evaluated at 4 time intervals and so the number of patients in every group may change at every time interval.

Group 4

Group 4: patients receiving spinal anesthesia and having a postoperative pain VAS score equal to or above 60 at 1st, 6th, 12th nd 24th hours the pain sores will be evaluated at 4 time intervals and so the number of patients in every group may change at every time interval.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All consecutive patients undergoing knee arthroplasty in 3 years period with general or spinal anesthesia.

You may qualify if:

• knee arthroplasty patients with general or spinal anesthesia.

You may not qualify if:

• patients not giving consent
• reoperations
• patients having inflammatory disease
• infection in the knee
• sepsis
• bleeding disorders
• hematologic diseases,
• using steroids.
• trauma
• fracture patients,
• bilateral knee prothesis
• combined surgery procedures
• patients needing perioperative transfusions
• uncooperative patients.

Sponsors & Collaborators

• Akdeniz University: lead

Study Sites (1)

AkdenizU

Antalya, 07058, Turkey (Türkiye)

Location

Related Links

• The role of mean platelet volume in patients with non-specific abdominal pain in an emergency department
• Neutrophil/Lymphocyte Ratio as a Predictor of In-Hospital Major Adverse Cardiac Events, New-Onset Atrial Fibrillation, and No-Reflow Phenomenon in Patients with ST Elevation Myocardial Infarction

MeSH Terms

Conditions

Pain, Postoperative

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• Ilker o Aycan, asso prof

  Akdeniz University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associated Professor

Study Record Dates

• First Submitted: May 2, 2017
• First Posted: May 11, 2017
• Study Start: June 28, 2017
• Primary Completion: January 31, 2018
• Study Completion: January 31, 2018
• Last Updated: January 13, 2023

Record last verified: 2023-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)