NCT03142386

Brief Summary

The aim of present study was to study the osteopathic manipulative effects on pain relief and quality of life improvement on hospitalized oncology geriatric patients. A non-randomized comparison trial was performed in Unit of Oncology Rehabilitation, Palazzolo Institute, Don Carlo Gnocchi Foundation ONLUS, Milan, Italy, from September 2015 to March 2016. 23 older oncology patients were unrolled and allocated in two experimental groups: study group (OMT group, N=12) underwent to osteopathic manipulative treatment associated to physiotherapy and control group (PT group, N = 11) underwent only physiotherapy. At enrollment (T0), 23 recruited oncology patients completed the socio-demographic forms and were evaluated, from external examiner, pain intensity and quality of life. All patients were revaluated at the end of treatment (T4) for quality of life and every week (T1, T2, T3 and T4) for pain intensity. Standard level of significance was p\<0.05.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
23

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Sep 2015

Shorter than P25 for not_applicable

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2015

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2015

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2016

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

April 28, 2017

Completed
7 days until next milestone

First Posted

Study publicly available on registry

May 5, 2017

Completed
Last Updated

May 5, 2017

Status Verified

May 1, 2017

Enrollment Period

3 months

First QC Date

April 28, 2017

Last Update Submit

May 3, 2017

Conditions

Keywords

geriatric oncologypainosteopathic manipulative treatmentquality of life

Outcome Measures

Primary Outcomes (1)

  • Pain

    Numeric Rating Scale (NRS) is a validated scale to measure the intensity of pain, with numbers between 0 and 10, with 0 representing absence of pain and 10 the worst possible pain experienced by the patient.

    Once a week for a total 4 weeks

Secondary Outcomes (1)

  • Quality of life

    At baseline and up to 4 weeks.

Study Arms (2)

OMT group

EXPERIMENTAL

Osteopathic manipulative treatment

Other: Osteopathic manipulative treatment

Control Group

ACTIVE COMPARATOR

Physiotherapy

Other: Physiotherapy

Interventions

Control Group

Eligibility Criteria

Age65 Years - 85 Years
Sexall
Healthy VolunteersNo
Age GroupsOlder Adult (65+)

You may qualify if:

  • oncology patients
  • male and female
  • age≥65 years
  • with a clinical prognosis of 6-24 months
  • diagnosis of multifactorial hyperkinetic syndrome (i.e. metastatic surgery)
  • pain intensity score higher than 3, measured with Numeric Rating Scale (NRS)

You may not qualify if:

  • patients were receiving chemotherapy or radiotherapy treatment at the time of the study
  • with mental disorders (MMSE\<10)
  • the presence of infection
  • anticoagulation therapy
  • cardiopulmonary disease
  • clinical instability post-surgery.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (1)

  • Arienti C, Bosisio T, Ratti S, Miglioli R, Negrini S. Osteopathic Manipulative Treatment Effect on Pain Relief and Quality of Life in Oncology Geriatric Patients: A Nonrandomized Controlled Clinical Trial. Integr Cancer Ther. 2018 Dec;17(4):1163-1171. doi: 10.1177/1534735418796954. Epub 2018 Aug 31.

MeSH Terms

Conditions

Pain

Interventions

Manipulation, OsteopathicPhysical Therapy Modalities

Condition Hierarchy (Ancestors)

Neurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Musculoskeletal ManipulationsComplementary TherapiesTherapeuticsRehabilitation

Study Officials

  • Chiara Arienti, PhD

    IRCCS Don Gnocchi Foundation

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
PhD

Study Record Dates

First Submitted

April 28, 2017

First Posted

May 5, 2017

Study Start

September 1, 2015

Primary Completion

December 1, 2015

Study Completion

March 1, 2016

Last Updated

May 5, 2017

Record last verified: 2017-05