BIOMECHANICAL AND MICROSTRUCTURAL PROPERTIES OF THE AORTIC WALL: A Pilot Study in Patients Undergoing Surgery for Ascending Aortic Aneurysms
Sponsor study identifier
observational
180
1 country
1
Study Start
January 2017
Actual (reported)Primary Completion
December 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
An aortic aneurysm (thoracic or abdominal) is a permanent dilatation of the aorta caused by weakening in the arterial wall. The feared complication is aortic rupture or dissection, leading to potentially lethal aortic bleeding and associated with mortality rates up to 95%. The current diagnosis criteria do not suffice, therefore the goal of this study is the development of an improved biomechanics-based and microstructural-based diagnostic tool.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
October 6, 2016
Actual (reported)January 2017
Actual (reported)May 5, 2017
Actual (reported)December 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Data collection of patients suffering from thoracic aortic aneurysms
General information (age, gender, height, weight, BMI); medicinal usage (beta-blockers, ACE inhibitors, statins, angiotensin receptor blockers, ...); cardiovascular risk factors (smoking, hypertension, dyslipidemia, diabetes, atrial fibrillation); cardiovascular properties (tricuspid aortic valve, inherited aortopathies, abdominal aortic aneurysm, prior open heart surgery, ...)
6 years
Investigation of correlation between rupture risk and mechanical and microstructural parameters
6 years
Biomechanical and microstructural analysis of ATAA ECG-gated CT
Tissue collection; microstructural testing of tissue; mechanical testing of tissue .
Image analysis of ECG-gated CT.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Patients suffering from ATAA
UZ Leuven
Leuven, Vlaams Brabant, 3000, Belgium
Aneurysmatic tissue
Bart Meuris, PhD
UZ Leuven
First Submitted
October 6, 2016
First Posted
May 5, 2017
Study Start
January 2017
Actual (reported)Primary Completion
December 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Neurophysiological Intraoperative Monitoring During Aortic Surgery
Contact the study team to confirm eligibility.
Study Completion
December 2025
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
July 1, 2024
Record last verified: 2024-06
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Source: ClinicalTrials.gov.
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