Intervention Comparative Effectiveness for Adult Cognitive Training

NCT03141281 | Completed Results DMC

• 1 other identifier: 2017.20622
• Study Type: interventional
• Target: 238
• Locations: 1 country
• Sites: 1

Brief Summary

The study will compare the effect of broad and directed (narrow) technology-based training on basic perceptual and cognitive abilities in older adults and on the performance of simulated tasks of daily living including driving and fraud avoidance.

Conditions

Cognitive Aging

Keywords

aging; cognitive ability; IADL; driving; financial fraud; perception; attention; memory

Outcome Measures

Primary Outcomes (22)

• Fraud Detection Post Training

  Percent confidence that a given vignette describing fraud is actually an example of fraud, measured at baseline and immediately after 4 weeks of training. Participants were given a vignette describing fraud (which was mixed in with vignettes not describing fraud) and were asked to give their percent confidence that this is actually an example of fraud. Higher confidence indicates higher accuracy when detecting fraud, with a minimum of 0 and a maximum of 100. Measures accuracy in discriminating fraud from non-fraud text-based scenarios (using 3 parallel forms).

  Baseline, Immediately after 4-week intervention training

• Driving Simulator Hazard Perception Post Training

  Driving simulator (scenarios including hazards) measures of speed, maximum brake compression, and lane position, at baseline and immediately after 4 weeks of training. These measures provide an estimate of accuracy in driving scenarios that involve hazards in the DriveSafety simulator (using 3 parallel forms). All measures were transformed into Z scores and averaged in order to create a measure of overall driving performance, where higher scores represent more dangerous (worse) driving performance.

  Baseline, Immediately after 4-week intervention training

• Self-reported Difficulty With Instrumental Activities of Daily Living (IADLs) Post Training

  Self-reported difficulties in completing instrumental activities of daily living, measured at baseline and immediately after 4 weeks of training, with a minimum score of 0 (indicating no difficulty) and a maximum of 3 (indicating severe difficulty). This is a modified short-form version of the Lawton IADL Items, used in the Multicenter AIDS Cohort Study (MACS).

  Baseline, Immediately after 4-week intervention training

• Speed of Processing Post Training

  Scores from Useful Field of View (UFOV) test and Digit Symbol Substitution Test, at baseline and immediately after 4 weeks of training, which each provide a measure of speed of processing. Raw scores were transformed into z scores, UFOV reaction time scores were inverted, then both UFOV and digit symbol scores were averaged in order to create an estimate of overall speed of processing, where higher scores represent better performance.

  Baseline, Immediately after 4-week intervention training

• Knowledge About Driving Post Training

  Test questions based on the American Association of Retired Persons driving course, measured immediately after 4 weeks of training, with a minimum score of 0 and a maximum score of 3. Higher scores indicate more accurate knowledge of driving related information.

  Immediately after 4-week intervention training

• Knowledge About Finances and Fraud Post Training

  Test questions based on the Finance and Fraud training tutorial, measured immediately after 4 weeks of training, with a minimum score of 0 and a maximum score of 3. Higher scores indicate more accurate knowledge of finance and fraud related information.

  Immediately after 4-week intervention training

• Fraud Detection at One Year

  Percent confidence that a given vignette describing fraud is actually an example of fraud, measured at baseline and one year after 4 weeks of training. Participants were given a vignette describing fraud (which was mixed in with vignettes not describing fraud) and were asked to give their percent confidence that this is actually an example of fraud. Higher confidence indicates higher accuracy when detecting fraud, with a minimum of 0 and a maximum of 100. Measures accuracy in discriminating fraud from non-fraud text-based scenarios (using 3 parallel forms).

  Baseline, One-year after 4-week intervention training

• Driving Simulator Hazard Perception at One Year

  Driving simulator (scenarios including hazards) measures of speed, maximum brake compression, and lane position, at baseline and one year after 4 weeks of training. These measures provide an estimate of accuracy in driving scenarios that involve hazards in the DriveSafety simulator (using 3 parallel forms). All measures were transformed into Z scores and averaged in order to create a measure of overall driving performance, where higher scores represent more dangerous (worse) driving performance.

  Baseline, One-year after 4-week intervention training

• Self-reported Difficulty With Instrumental Activities of Daily Living (IADLs) at One Year

  Self-reported difficulties in completing instrumental activities of daily living, measured at baseline and one year after 4 weeks of training, with a minimum score of 0 (indicating no difficulty) and a maximum of 3 (indicating severe difficulty).This is a modified short-form version of the Lawton IADL Items, used in the Multicenter AIDS Cohort Study (MACS).

  Baseline, One-year after 4-week intervention training

• Speed of Processing at One Year

  Scores from Useful Field of View (UFOV) test and Digit Symbol Substitution Test, at baseline and one year after 4 weeks of training, which each provide a measure of speed of processing. Raw scores were transformed into z scores, UFOV reaction time scores were inverted, then UFOV and digit symbol scores were averaged in order to create an estimate of overall speed of processing, where higher scores represent better performance.

  Baseline, One-year after 4-week intervention training

• Knowledge About Driving at One Year

  Test questions based on the American Association of Retired Persons driving course, measured one year after 4 weeks of training, with a minimum score of 0 and a maximum score of 3. Higher scores indicate more accurate knowledge of driving related information.

  One-year after 4-week intervention training

• Knowledge About Finances and Fraud at One Year

  Test questions based on the Finance and Fraud training tutorial, measured immediately after one year of training, with a minimum score of 0 and a maximum score of 3. Higher scores indicate more accurate knowledge of finance and fraud related information.

  One-year after 4-week intervention training

• Driving Simulator Average Speed Post Training

  Average speed in a driving simulator measured at baseline and immediately after 4 weeks of training. Speed is a continuous measure in miles per hour, with a minimum of 0 and no maximum. Speed may indicate risky driving behavior.

  Baseline, Immediately after 4-week intervention training

• Driving Simulator Max Brake Compression Post Training

  Maximum brake compression in a driving simulator measured at baseline and immediately after 4 weeks of training. Maximum brake compression measures the most that the brake pedal was compressed during driving, with a minimum of 0 and a maximum of 1. Maximum brake compression may indicate urgent stopping.

  Baseline, Immediately after 4-week intervention training

• Driving Simulator Average Lane Position Post Training

  Average lane position in a driving simulator measured at baseline and immediately after 4 weeks of training. Lane position measures the average deviation from the center of a lane while driving (values from -1 to 1), averaged across participants, where 0 represents perfect center, negative scores represent deviation to the left (from 0 to -1), and positive scores represent deviation to the right (from 0 to 1). Lane position indicates vehicle control and safety.

  Baseline, Immediately after 4-week intervention training

• Driving Simulator Average Speed at One Year

  Average speed in a driving simulator measured at baseline and one year after 4 weeks of training. Speed is a continuous measure in miles per hour, with a minimum of 0 and no maximum. Speed may indicate risky driving behavior.

  Baseline, One-year after 4-week intervention training

• Driving Simulator Max Brake Compression at One Year

  Maximum brake compression in a driving simulator measured at baseline and one year after 4 weeks of training. Maximum brake compression measures the most that the brake pedal was compressed during driving, with a minimum of 0 and a maximum of 1. Maximum brake compression may indicate urgent stopping.

  Baseline, One-year after 4-week intervention training

• Driving Simulator Average Lane Position at One Year

  Average lane position in a driving simulator measured at baseline and one year after 4 weeks of training. Lane position measures the average deviation from the center of a lane while driving (values from -1 to 1), averaged across participants, where 0 represents perfect center, negative scores represent deviation to the left (from 0 to -1), and positive scores represent deviation to the right (from 0 to 1). Lane position indicates vehicle control and safety.

  Baseline, One-year after 4-week intervention training

• Useful Field of View Post Training

  Useful field of view (UFOV) measured at baseline and immediately after 4 weeks of training. UFOV is measured as a response time in milliseconds, with lower times indicating quicker responses.

  Baseline, Immediately after 4-week intervention training

• Digit Symbol Substitution Test Post Training

  The Digit Symbol Substitution Test measured at baseline and immediately after 4 weeks of training. The Digit Symbol Substitution Test is measured through the number of items completed during a 90 second period, where higher scores indicate faster/better performance.

  Baseline, Immediately after 4-week intervention training

• Useful Field of View at One Year

  Useful field of view (UFOV) measured at baseline and one year after 4 weeks of training. UFOV is measured as a response time in milliseconds, with lower times indicating quicker responses.

  Baseline, One-year after 4-week intervention training

• Digit Symbol Substitution Test at One Year

  The Digit Symbol Substitution Test measured at baseline and one year after 4 weeks of training. The Digit Symbol Substitution Test is measured through the number of items completed during a 90 second period, where higher scores indicate faster/better performance.

  Baseline, One-year after 4-week intervention training

Secondary Outcomes (10)

• Technology Proficiency Post Training

  Baseline, Immediately after 4-week intervention training

• Technology Proficiency at One Year

  Baseline, One-year after 4-week intervention training

• Numeracy Post Training

  Baseline, Immediately after 4-week intervention training

• Numeracy at One Year

  Baseline, One-year after 4-week intervention training

• Reasoning Ability Post Training

  Baseline, Immediately after 4-week intervention training

Study Arms (4)

BrainHQ

EXPERIMENTAL

Participants will be provided with a laptop computer and enrolled in a commercial web-based cognitive training program, BrainHQ, trained on how to access it, and instructed to complete a fixed number of sessions in 20 hours.

Behavioral: BrainHQ

Rise of Nations

EXPERIMENTAL

Participants will be provided with a laptop computer with the Rise of Nations video game, be trained in game play, and instructed to play the game for 20 hours

Behavioral: Rise of Nations

IADL training

EXPERIMENTAL

Participants will be enrolled in American Association of Retired Persons' web-based driver training course, trained on how to access it, and asked to complete the course, estimated to take approximately 6-8 hours. They will also be provided with web-based access to a finance and fraud avoidance training tutorial, instructed on how to access it, and be asked to complete the course, estimated to take approximately 5-7 hours. The two courses combined are estimated to take about 15 hours.

Behavioral: IADL Training

Active Control

ACTIVE COMPARATOR

Participants will be provided with a laptop computer and asked to complete 20 hr of training with Sudoku, crossword puzzles, and word search

Behavioral: Active Control

Interventions

BrainHQ BEHAVIORAL

BrainHQ

BrainHQ

Rise of Nations BEHAVIORAL

Rise of Nations

Rise of Nations

IADL Training BEHAVIORAL

IADL Training

IADL training

Active Control BEHAVIORAL

Puzzle solving

Active Control

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Age 65 years and above
• Plans to stay in the Tallahassee, Leon County area for the next year
• Valid driver's license and drives at least once a month
• Adequate cognitive ability assessed via telephone interview using the Wechsler Memory Scale III with story A score \>6 or story B score \>4.

You may not qualify if:

• Terminal illness with life expectancy less than 12 months
• Reports or exhibits a disabling visual condition assessed as the inability to read printed material
• Reports or exhibits a disabling speech hearing and comprehension condition assessed by inability to hear and comprehend the screener's instructions
• Reports or exhibits a disabling speech production condition assessed as the inability to respond with comprehensible English speech to the screener's queries
• Reports or exhibits a disabling psychomotor condition assessed as the inability to use a keyboard and pointing device
• Has completed the AARP driver training course
• Has played the Rise of Nations video game
• Has trained with Posit Science's "BrainHQ"
• Has trained on the Mind Frontiers video game.

Sponsors & Collaborators

• Florida State University: lead

Study Sites (1)

Florida State University

Tallahassee, Florida, 32306-4301, United States

Location

Related Publications (2)

• Gray N, Yoon JS, Charness N, Boot WR, Roque NA, Andringa R, Harrell ER, Lewis KG, Vitale T. Relative effectiveness of general versus specific cognitive training for aging adults. Psychol Aging. 2022 Mar;37(2):210-221. doi: 10.1037/pag0000663. Epub 2021 Dec 30.

  PMID: 34968102 DERIVED

• Yoon JS, Roque NA, Andringa R, Harrell ER, Lewis KG, Vitale T, Charness N, Boot WR. Intervention Comparative Effectiveness for Adult Cognitive Training (ICE-ACT) Trial: Rationale, design, and baseline characteristics. Contemp Clin Trials. 2019 Mar;78:76-87. doi: 10.1016/j.cct.2019.01.014. Epub 2019 Jan 31.

  PMID: 30711665 DERIVED

Results Point of Contact

• Title: Dr. Neil Charness
• Organization: Florida State University

charness@psy.fsu.edu

850-644-6686

Study Officials

• Neil Charness, PhD

  Florida State University

  PRINCIPAL INVESTIGATOR

• Walter Boot, PhD

  Florida State University

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Assessors will be blinded to study condition when administering the tests to participants
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator, Professor of Psychology

Model Details: Random assignment to one of four treatment groups at study entry

Study Record Dates

• First Submitted: May 1, 2017
• First Posted: May 5, 2017
• Study Start: September 20, 2017
• Primary Completion: September 3, 2019
• Study Completion: September 3, 2019
• Last Updated: June 7, 2021
• Results First Posted: June 7, 2021

Record last verified: 2021-05

Locations

US (1)