Measurement of MSFP and Stressed Volume With CardioQ+®
Measurement of Mean Systemic Filling Pressure & Stressed Volume With CardioQ+® Oesophageal Doppler Measurement
1 other identifier
observational
42
1 country
1
Brief Summary
To study the reliablity of MSFP and stressed volume to follow volume loading and to predict fload loading responsiveness in patients after elective coronary artery bypass grafting (CABG) surgery.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started May 2017
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 3, 2017
CompletedFirst Posted
Study publicly available on registry
May 4, 2017
CompletedStudy Start
First participant enrolled
May 9, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 5, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
March 1, 2020
CompletedJanuary 13, 2020
January 1, 2020
2 years
April 3, 2017
January 9, 2020
Conditions
Outcome Measures
Primary Outcomes (2)
MSFPhold
Mean systemic filling pressure
Before and after fluid administration (2 minutes and 10 minutes)
MSFParm
Mean systemic filling pressure
Before and after fluid administration (2 minutes and 10 minutes)
Secondary Outcomes (1)
Stressed volume
Before and after fluid administration (2 minutes and 10 minutes)
Other Outcomes (5)
Vascular compliance (Csys)
Before and after fluid administration (2 minutes and 10 minutes)
CVP
Before and after fluid administration (2 minutes and 10 minutes)
PPV
Before and after fluid administration (2 minutes and 10 minutes)
- +2 more other outcomes
Interventions
MSFPhold and MSFParm
Eligibility Criteria
CABG
You may qualify if:
- Patients 18 years and older planned for CABG
You may not qualify if:
- Contraindication for fluid loading
- Pregnancy, morbid obesity
- Hemodynamic instability with a mean arterial pressure (MAP) \< 55 mm Hg and/ or a cardiac index \< 1.5 L•min-1
- Severe arrhythmias
- Intra-cardiac shunts
- Symptomatic peripheral vascular disease
- Symptomatic pulmonary disease
- Significant valvular regurgitation
- Poor pre-operative left or right ventricular function
- Core temperature \< 36 °C
- Contra-indication to the rapid cuff inflator
- Contra-indication to oesophageal Doppler probe insertion.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Academic Medical Center Amsterdam
Amsterdam, Netherlands
Related Publications (1)
Wijnberge M, Jansen JRC, Pinsky MR, Klanderman RB, Terwindt LE, Bosboom JJ, Lemmers N, Vlaar AP, Veelo DP, Geerts BF. Feasibility to estimate mean systemic filling pressure with inspiratory holds at the bedside. Front Physiol. 2022 Nov 29;13:1041730. doi: 10.3389/fphys.2022.1041730. eCollection 2022.
PMID: 36523553DERIVED
Biospecimen
Blood samples
Study Officials
- PRINCIPAL INVESTIGATOR
Bart Geerts, MD, PhD
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD PhD
Study Record Dates
First Submitted
April 3, 2017
First Posted
May 4, 2017
Study Start
May 9, 2017
Primary Completion
May 5, 2019
Study Completion
March 1, 2020
Last Updated
January 13, 2020
Record last verified: 2020-01
Data Sharing
- IPD Sharing
- Will not share