Upper Limb Function and Visuospatial Exploration After Stroke

NCT03135093 | Completed

• 1 other identifier: 2016-02075
• Study Type: observational
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

This project is a cross-sectional, observational mono-center study with prospective data collecting. This study aims to further explore quality of upper limb movement in relation to characteristics of visuospatial exploration in stroke subjects and healthy subjects by a applying comprehensive measurements of clinical scales and kinematic data in capacity- and performance-based activities. The results will contribute to assessing and monitoring quality of upper limb movements and visuospatial attention and their relationship.

Conditions

Stroke

Keywords

synergies; upper limb; vision

Outcome Measures

Primary Outcomes (2)

• Upper limb movement quality

  Fugl-Meyer Assessment of the upper extremity (FMA-UE), kinematic data (e.g. joint angles, hand workspace)

  One day

• Visuospatial exploration

  Eye-tracking data (e.g. area of interest, eye movements: saccades, fixations) and to rule out stroke-related deficits of visuospatial attention, clinical tests

  One day

Study Arms (2)

Stroke subjects

Other: No intervention

Healthy subjects

Other: No intervention

Interventions

No intervention OTHER

No Intervention

Healthy subjects; Stroke subjects

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Stroke subjects

You may qualify if:

• Subjects of 18 years and older with chronic ischemic stroke (\> 6 month) restricted to one hemisphere (confirmed by CT/MRI)
• With impairments in upper limb function and at least partial ability to lift the arm against gravity, flex and extend the fingers
• Without relevant pre-existing limitations in arm and hand function (orthopaedic, muscular, neurologic)
• Written informed consent after participants's information

You may not qualify if:

• Increased muscle tone in the upper limb with limited rang of motion
• Severe sensory deficits in the upper limb
• Clinically significant concomitant disease (affecting the upper limb or impaired vision, e.g. due to glaucoma etc.)
• Contraindications on ethical grounds (vulnerable persons)
• Known or suspected non-compliance, drug or alcohol abuse
• Severe communication or cognitive deficits, that cause inability to follow the procedures

Sponsors & Collaborators

• University of Zurich: lead

Study Sites (1)

cereneo Schweiz AG

Vitznau, Canton of Lucerne, 6345, Switzerland

Location

Related Publications (2)

• Schwarz A, Bhagubai MMC, Nies SHG, Held JPO, Veltink PH, Buurke JH, Luft AR. Characterization of stroke-related upper limb motor impairments across various upper limb activities by use of kinematic core set measures. J Neuroeng Rehabil. 2022 Jan 12;19(1):2. doi: 10.1186/s12984-021-00979-0.

  PMID: 35016694 DERIVED

• Schwarz A, Veerbeek JM, Held JPO, Buurke JH, Luft AR. Measures of Interjoint Coordination Post-stroke Across Different Upper Limb Movement Tasks. Front Bioeng Biotechnol. 2021 Jan 28;8:620805. doi: 10.3389/fbioe.2020.620805. eCollection 2020.

  PMID: 33585418 DERIVED

MeSH Terms

Conditions

Stroke

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 26, 2017
• First Posted: May 1, 2017
• Study Start: April 1, 2017
• Primary Completion: December 30, 2019
• Study Completion: December 30, 2019
• Last Updated: February 11, 2020

Record last verified: 2020-01

Data Sharing

• IPD Sharing: Will share

Locations

CH (1)