Aortitis and Retroperitoneal Fibrosis: Evaluation of Diagnostic Criteria

NCT03133949 | Unknown

• 1 other identifier: PHRCIR09-DR-SCHMIDT
• Study Type: observational
• Target: 206
• Locations: 1 country
• Sites: 1

Brief Summary

Inflammatory aortitis probably represents a heterogeneous group, and the clinical experience accumulated over the last ten years, shared by the experts of the subject, is that the initial clinical, biological or radiological characteristics should make it possible to differentiate them and dismember the Nosological field. This will be an essential first step before studying prognosis, risk factors, and therapeutic options. The search for diagnostic criteria on a large series, similar to the study of classification of vascularites of the ACR in 1990, should make it possible to homogenize the diagnoses for the different teams working on the subject, and to begin work Collaborations, which alone can improve patient care in the future.

Conditions

Idiopathic Aortitis; Retroperitoneal Fibrosis

Outcome Measures

Primary Outcomes (1)

• Analyze the management of patients with aortic and retroperitoneal fibrosis

  1 day

Study Arms (2)

Patients with idiopathic inflammatory aortitis

Other: Establish the clinical, biological and radiological characteristics of patients

a group of witnesses

Other: Establish the clinical, biological and radiological characteristics of patients

Interventions

Establish the clinical, biological and radiological characteristics of patients OTHER

Establish the clinical, biological and radiological characteristics of patients

Patients with idiopathic inflammatory aortitis; a group of witnesses

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients with idiopathic inflammatory aortitis or retroperitoneal fibrosis. Three focus groups will be constituted: Group 1: it will include all cases of non-idiopathic inflammatory aortitis followed in the participating centers over the last 15 years, Group 2: it will include patients with non-inflammatory aortic conditions (aneurysm, atheroma, annulo-ectasitic aortic disease). Group 3: it will include patients without aortic pathology matched by age and sex, having a thoracoabdominal scanner or MRI in the participating centers.

You may qualify if:

• Cases :
• All cases of idiopathic aortitis and retroperitoneal fibrosis followed in participating centers over the past 15 years will be collected.
• Witnesses :
• Group 1: non-idiopathic inflammatory aortitis: all cases of inflammatory aortitis (apart from idiopathic aortites and isolated retroperitoneal fibrosis) followed in the participating centers over the last 15 years will be collected.
• Group 2: subjects with noninflammatory aortic disease, atheromatous type or annulo-ectasitic disease, matched by age and sex with cases. This group will be used to define the differential characteristics between idiopathic aortitis and noninflammatory aortic pathology.
• Group 3: This group will include control subjects aimed at defining radiological normality criteria according to age and sex. As the images are machine-dependent, group 3 controls will be randomly selected from the radiology departments that have performed the scanner or MRI of the corresponding control.

You may not qualify if:

• Patients under 18 years of age

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

CHU Amiens Picardie

Amiens, Picardie, 80054, France

RECRUITING

MeSH Terms

Conditions

Retroperitoneal Fibrosis

Interventions

Biological Products

Condition Hierarchy (Ancestors)

Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Complex Mixtures

Central Study Contacts

Jean SCHMIDT, PhD

CONTACT

+33322668230; schmidt.jean@chu-amiens.fr

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 13, 2017
• First Posted: April 28, 2017
• Study Start: July 8, 2010
• Primary Completion: July 8, 2020
• Study Completion: July 8, 2020
• Last Updated: April 28, 2017

Record last verified: 2017-04

Locations

FR (1)