Polypharmacy and Outcomes After Elective Noncardiac Surgery

NCT03133182 | Completed Results

• 1 other identifier: DM5
• Study Type: observational
• Target: 266,499
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study investigates the association of preoperative polypharmacy with outcomes and healthcare resource utilization in a population-based sample of older patients enrolled in a universal pharmacare program

Conditions

Polypharmacy; Surgical Procedure, Operative; Morality; Epidemiology

Outcome Measures

Primary Outcomes (1)

• Mortality

  death from any cause

  from day of surgery up to 90 days after surgery

Secondary Outcomes (5)

• Complications

  From day of surgery to day of hospital discharge, up to 365 days after surgery

• Length of Stay

  date of surgery to date of hospital discharge, or 365 days after surgery, whichever comes first

• Costs of Care

  date of surgery up to 90 days after surgery

• Institutional Discharge

  date of surgery to date of hospital discharge, or 365 days after surgery, whichever comes first

• Hospital Readmission

  From the date of hospital discharge to 30 days after the date of discharge

Study Arms (2)

Polypharmacy

People taking \>=5 unique prescription drugs in the 3 months prior to surgery

Drug: Polypharmacy

No polypharmacy

People taking \<5 unique prescription drugs in the 3 months prior to surgery

Interventions

Polypharmacy DRUG

Patients who are taking \>=5 unique prescription drugs in the 3 months prior to surgery

Polypharmacy

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Population-based sample of people having their first eligible surgery during the study period

You may qualify if:

• Intermediate to high risk elective non-cardiac surgery
• Age \>=66 on day of surgery

Sponsors & Collaborators

• Ottawa Hospital Research Institute: lead

Related Publications (1)

• McIsaac DI, Wong CA, Bryson GL, van Walraven C. Association of Polypharmacy with Survival, Complications, and Healthcare Resource Use after Elective Noncardiac Surgery: A Population-based Cohort Study. Anesthesiology. 2018 Jun;128(6):1140-1150. doi: 10.1097/ALN.0000000000002124.

  PMID: 29443701 DERIVED

MeSH Terms

Interventions

Polypharmacy

Intervention Hierarchy (Ancestors)

Drug Therapy; Therapeutics; Overtreatment; Medical Overuse; Health Services Misuse; Health Services; Health Care Facilities Workforce and Services; Attitude to Health; Delivery of Health Care; Health Care Quality, Access, and Evaluation

Limitations and Caveats

We are unable to fully account for unmeasured confounders and indication bias. We were not able to account for granular patient-level data. We used health administrative data that were not initially collected for research purposes; risk of misclassification bias should be considered. Our polypharmacy exposure did not account for the potential differing risk impacts or appropriateness of different drugs. We were unable to account for medication underutilization which could bias results.

Results Point of Contact

• Title: Dr. Daniel McIsaac
• Organization: The Ottawa Hospital

dmcisaac@toh.ca

613-761-4940

Publication Agreements

• PI is Sponsor Employee: No
• Restrictive Agreement: No

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 18, 2017
• First Posted: April 28, 2017
• Study Start: April 1, 2002
• Primary Completion: March 1, 2014
• Study Completion: March 1, 2014
• Last Updated: January 24, 2025
• Results First Posted: January 24, 2025

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share