NCT03125668

Brief Summary

The purpose of this study is to test an educational program with telephone follow-up to improve health-related quality of life (HRQoL), treatment adherence, and reduce anxiety and depression symptoms in patients who are starting oral anticoagulants (OA).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
52

participants targeted

Target at P25-P50 for not_applicable quality-of-life

Timeline
Completed

Started Oct 2015

Typical duration for not_applicable quality-of-life

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2015

Completed
1.4 years until next milestone

First Submitted

Initial submission to the registry

February 22, 2017

Completed
2 months until next milestone

First Posted

Study publicly available on registry

April 24, 2017

Completed
1 month until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 30, 2017

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

November 30, 2017

Completed
Last Updated

March 30, 2020

Status Verified

March 1, 2020

Enrollment Period

1.7 years

First QC Date

February 22, 2017

Last Update Submit

March 26, 2020

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change in Health-Related Quality of Life

    The Duke Anticoagulation Satisfaction Scale (DASS) was developed by Samsa et al. (2004) and validated for the Brazilian population by Pelegrino et al. (2011). The scale have 25 items divided in three domains: Limitation (9 items); Hassles and burdens (8 items); Psychological Impacts (8 items). All items have seven response categories: "not at all", "a little", "somewhat", "moderately", "quite a bit", "a lot", and "very much". Possible range: 25 to 175 and lower scores, indicated better Health-Related Quality of Life.

    Three and six months after hospital discharge

Secondary Outcomes (3)

  • Change in Symptoms of Anxiety and Depression

    At baseline, Three and six months after hospital discharge.

  • Adherence

    INR values during the six months follow-up

  • Assessment and frequency of adverse events related to Warfarin

    Three and six months after hospital discharge

Study Arms (2)

Intervention Group

EXPERIMENTAL

At the hospitalization, patients receive the educational program (Power Point®Slides, booklets and orientation) about the use of warfarin. After hospital discharge they receive a telephone follow-up (five calls) and two Face to face counseling.

Behavioral: Educational ProgramBehavioral: Telephone follow-upBehavioral: Face to face counseling

Control Group

ACTIVE COMPARATOR

At the hospitalization, patients receive the educational program (Power Point®Slides, booklets and orientation) about the use of warfarin. After hospital discharge they receive two face to face counseling.

Behavioral: Educational ProgramBehavioral: Face to face counseling

Interventions

At the hospitalization, patients receive the educational program with Power Point®Slides, booklets and orientation about the use of warfarin.

Control GroupIntervention Group

After hospital discharge they receive a telephone follow-up (five calls for six months: 1st call in one week and the others calls month by month until six months). During the telephone calls the researcher talk with the patient about the topics that were approach in the educational intervention and motivate the patient to follow the recommendations for they have a successful treatment.

Intervention Group

They receive two face to face counseling (1st meeting in three months and the 2nd meeting in six months after hospital discharge). In the face to face counseling the researcher collect the data about anxiety and depression again, health-related quality of life and adverse events related to oral anticoagulation therapy.

Control GroupIntervention Group

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age over 18 years;
  • Both genders;
  • To start the use of Warfarin for the first time during the current hospitalization;
  • To have a phone.

You may not qualify if:

  • To start the Oral Anticoagulation Therapy with another oral anticoagulant;
  • To start the Warfarin for surgical procedures;
  • To have visual or hearing impairments;
  • Don't have cognitive conditions\* to answer the questions of data collection instruments (measured by adapted questions from Pfiefer (1975);
  • To have a cancer diagnosis.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo

Ribeirão Preto, São Paulo, 14040902, Brazil

Location

MeSH Terms

Conditions

Health EducationPatient Compliance

Condition Hierarchy (Ancestors)

Adherence InterventionsMedication AdherencePatient Acceptance of Health CareTreatment Adherence and ComplianceHealth BehaviorBehavior

Study Officials

  • Rosana S Dantas, PhD

    University of São Paulo at Ribeirão Preto College of Nursing

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

February 22, 2017

First Posted

April 24, 2017

Study Start

October 1, 2015

Primary Completion

May 30, 2017

Study Completion

November 30, 2017

Last Updated

March 30, 2020

Record last verified: 2020-03

Data Sharing

IPD Sharing
Will not share

Locations