NCT03123224

Brief Summary

This study evaluates the effect of a physical exercise + caregiver skills training on feelings of burden, mood, and biological markers of inflammation in persons who provide care for Veterans with a TBI or dementia. Half of the caregivers will participate in a balance and flexibility + caregiver skills training program, while the other half will participate in a moderate/high intensity aerobic and resistance + caregiver skills training program.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
200

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Aug 2015

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

August 1, 2015

Completed
1.7 years until next milestone

First Submitted

Initial submission to the registry

April 3, 2017

Completed
18 days until next milestone

First Posted

Study publicly available on registry

April 21, 2017

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2018

Completed
Last Updated

January 18, 2018

Status Verified

January 1, 2018

Enrollment Period

2.9 years

First QC Date

April 3, 2017

Last Update Submit

January 16, 2018

Conditions

Keywords

CaregiverCaregivingTBIdementiaAlzheimer's diseasephysical exercisephysical activitypsychosocialcaregiver skills training

Outcome Measures

Primary Outcomes (1)

  • Caregiver Burden using Zarit Burden Inventory

    Zarit Burden Inventory

    Six Months

Study Arms (2)

Combined Aerobic and Resistance Exercise

EXPERIMENTAL

Participants will work with study staff to develop an individualized physical training program based on their level of functioning at study entry. Exercises will focus on increasing the heart rate to a point at which participants will breathe more heavily and may sweat.

Behavioral: Combined Aerobic and Resistance Exercise + Caregiver Skills Training

Balance and Flexibility

ACTIVE COMPARATOR

Participants will work with study staff to develop an individualized physical training program based on their level of functioning at study entry.

Behavioral: Stretching Balance and Flexibility + Caregiver Skills Training

Interventions

The combined moderate to high intensity combined aerobic and resistance exercise training + skills training group consists of six months of physical exercise + caregiver skills training followed by an additional six months of follow-up for a total study duration of twelve months. All aspects of these combined interventions will be delivered through mobile technology thus obviating some of the obstacles to caregivers face in meeting their own needs. Caregivers will be provided with study issued equipment (e.g., exercise equipment, activity monitoring devices, and tablets) to complete all elements of the intervention.

Combined Aerobic and Resistance Exercise

The stretching, balance and flexibility training + skills training group consists of six months of physical exercise + caregiver skills training followed by an additional six months of follow-up for a total study duration of twelve months. All aspects of these combined interventions will be delivered through mobile technology thus obviating some of the obstacles to caregivers face in meeting their own needs. Caregivers will be provided with study issued equipment (e.g., exercise equipment, activity monitoring devices, and tablets) to complete all elements of the intervention.

Balance and Flexibility

Eligibility Criteria

Age18 Years - 85 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • individuals aged 18 - 85
  • distress associated with being the primary caregiver of a person with TBI or dementia
  • endorsement of at least two of the following items: felt overwhelmed, felt like needed to cry, angry or frustrated, distant or cut of from family or friends, moderate to high levels of stress, felt their health had declined
  • provide at least one hour of care (supervision or direct assistance) per week over the past three months
  • approval by Primary Care Provider to participate in physical exercise
  • be proficient in spoken and written English

You may not qualify if:

  • current or lifetime history of any psychiatric disorder with psychotic features
  • prominent suicidal or homicidal ideation
  • current alcohol or substance abuse
  • diagnosis of probable or possible dementia
  • a Short Portable Mental Status score of ≥ 8
  • participation in another caregiver intervention within the past year
  • lack of regular access to the internet
  • planned transfer of care recipient to another caregiver or nursing home within 12 months; 8) current severe cardiac disease (e.g., uncontrolled atrial fibrillation, defined as mean 24 hour heart rate \>85 beats/min, or 24 hour maximal ventricular rate \>150 beats/min; uncontrolled ventricular arrhythmias, defined as recurrent ventricular tachycardia \>3 beats in succession, or 24 hour PVC count \>20%; active pericarditis or myocarditis; Class III/IV heart failure and / or ejection fraction \< 20%; thrombophlebitis; pulmonary disease with a drop in O2 Sat with exercise to 90% without oxygen; embolism within past 6 months)
  • inability to participate in an exercise stress test
  • morbid obesity (BMI \> 39)
  • inability to read, verbalize understanding and voluntarily sign the Informed Consent.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

VA Palo Alto Health Care System

Palo Alto, California, 94304, United States

RECRUITING

MeSH Terms

Conditions

Brain Injuries, TraumaticAlzheimer DiseaseDementiaCraniocerebral TraumaBrain ConcussionMotor Activity

Interventions

Pliability

Condition Hierarchy (Ancestors)

Brain InjuriesBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesTrauma, Nervous SystemWounds and InjuriesTauopathiesNeurodegenerative DiseasesNeurocognitive DisordersMental DisordersHead Injuries, ClosedWounds, NonpenetratingBehavior

Intervention Hierarchy (Ancestors)

Mechanical PhenomenaPhysical Phenomena

Central Study Contacts

Jennifer Fairchild, PhD

CONTACT

Marisol Hernandez

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

April 3, 2017

First Posted

April 21, 2017

Study Start

August 1, 2015

Primary Completion

July 1, 2018

Study Completion

July 1, 2018

Last Updated

January 18, 2018

Record last verified: 2018-01

Data Sharing

IPD Sharing
Will not share

Locations