NCT03121768

Brief Summary

A prospective observational study to re-establish a new prognostic model for predicting the outcome in patients with non-muscle invasive bladder cancer (NMIBC) using the current recommendation regimen for intermediate and high risk groups and including all potential and highly prognostic factors.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
761

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started May 2017

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 15, 2017

Completed
1 month until next milestone

First Posted

Study publicly available on registry

April 20, 2017

Completed
25 days until next milestone

Study Start

First participant enrolled

May 15, 2017

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2019

Completed
2.3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2022

Completed
Last Updated

May 16, 2017

Status Verified

May 1, 2017

Enrollment Period

2.5 years

First QC Date

March 15, 2017

Last Update Submit

May 14, 2017

Conditions

Keywords

Prognostic ModelBladder CancerSuperficial Bladder CancerRecurrenceProgressionBCG

Outcome Measures

Primary Outcomes (1)

  • Construct a new prognostic model for the prediction of recurrence and progression of NMIBC

    Outcome Measure by counting and cmparing number of patients surviving for two year without tumor recurrence or progression to muscle invasive bladder cancer

    2 years

Secondary Outcomes (2)

  • cancer-specific survival (CSS) after treatment of NMIBC

    5 years

  • overall survival (OS) after treatment of NMIBC

    5 years

Eligibility Criteria

Age18 Years+
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Eligible patient presented with NMIBC will be asked to participate in this study and will be provided with an informed consent form in line with Good Clinical Practise and the Declaration of Helsinki.

You may qualify if:

  • Patient with NMIBC

You may not qualify if:

  • Refuse to complete study requirements
  • Contraindication to BCG therapy
  • Muscle invasive disease

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Urology and Nephrology Center

Mansora, Aldakahlia, 35516, Egypt

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

bladder biopsy of TURBT

MeSH Terms

Conditions

NeoplasmsUrinary Bladder NeoplasmsNon-Muscle Invasive Bladder NeoplasmsRecurrenceDisease Progression

Condition Hierarchy (Ancestors)

Urologic NeoplasmsUrogenital NeoplasmsNeoplasms by SiteFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesUrinary Bladder DiseasesUrologic DiseasesMale Urogenital DiseasesCarcinomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic TypeDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Ahmed Mosbah, MD

    Urology and Nephrology Center

    STUDY CHAIR

Central Study Contacts

Abdelwahab R. Hashem, Msc

CONTACT

Ahmed M Harraz, MD

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Msc

Study Record Dates

First Submitted

March 15, 2017

First Posted

April 20, 2017

Study Start

May 15, 2017

Primary Completion

December 1, 2019

Study Completion

April 1, 2022

Last Updated

May 16, 2017

Record last verified: 2017-05

Data Sharing

IPD Sharing
Will share

meta-analyses by contact the Prof. Ahmed Mosbah MD (Study Chair)

Locations