Periodized Aerobic Interval Training in Metabolic Syndrome

NCT03119493 | Completed DMC

• 1 other identifier: 53117116000005402
• Study Type: interventional
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

Autonomic disfunction present in metabolic syndrome subjects is related by a greater vulnerability of the heart and risk of cardiovascular events. In this context, aerobic interval training has been highlighted by its easy applicability and benefits effects in autonomic modulation in different populations. Therefore the studies that use de aerobic interval training in this different populations didn't realize a periodization of training with preparatory periods with progressive increase of load, specific phases with less duration predominating the intensity and transition periods for recuperation. Additionally, there isn't studies that investigate the effects of aerobic interval training in autonomic modulation of individuals with metabolic syndrome. In this context, periodized aerobic interval training can arise like a new type of treatment that offering security and efficacy in subjects with metabolic syndrome. So, the aim of the study is evaluate the effect of periodized aerobic interval training in cardiac autonomic modulation and cardiovascular and anthropometric parameters of individuals with metabolic syndrome.

Conditions

Metabolic Syndrome; Metabolic Syndrome X

Keywords

Metabolic syndrome X; Autonomic nervous system; Aerobic exercise; Exercise; Heart rate

Outcome Measures

Primary Outcomes (1)

• Heart rate variability

  16 week after allocation

Secondary Outcomes (5)

• Cardiovascular parameter : heart rate

  16 week after allocation

• Cardiovascular parameter: blood pressure

  16 week after allocation

• Anthropometric parameter: hit waist ratio

  16 week after allocation

• Anthropometric parameter: abdominal circumference

  16 week after allocation

• Anthropometric parameter: body mass index

  16 week after allocation

Study Arms (2)

Periodized aerobic interval training

EXPERIMENTAL

The experimental groups will participate in a 16 week, three times a week based-program of periodized aerobic interval training that consist in warming \[5 minutes of general stretching and 5 minutes of walking on treadmill with heart rate less than 20 percent of heart rate reserve (HHR)\], followed by periodized aerobic interval training on treadmill, and cooling down \[5 minutes of walk in treadmill with a heart rate less than 20 percent of HRR and 5 minutes of rest\]

Behavioral: Periodized aerobic interval training

Control group

NO INTERVENTION

Participants in the control group will be instructed not to take part in any regular exercise programs during the study period.

Interventions

Periodized aerobic interval training BEHAVIORAL

The periodized training program consist in 3 phases: light (I) (training range varying between 20 to 39% of heart rate reserve and active recuperation of 19% of heart rate reserve); moderate (II) (training range varying between 40 to 59% of heart rate reserve and active recuperation of 30% of heart rate reserve) and high (III) (training range varying between 70 to 90 % of heart rate reserve and active recuperation of 50% of heart rate reserve).

Periodized aerobic interval training

Eligibility Criteria

• Age: 40 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Metabolic syndrome according to international diabetes federation (IDF) definition
• Aged between 40 to 60 years

You may not qualify if:

• Participants who are currently participating in any regular exercise programs last six months;
• Use of drugs or medication (Except for risk factors of metabolic syndrome control);
• Inflammatory or infectious process;
• Musculotendinous or osteoarticular injuries in the lower limbs and/or spine;
• Chronic pulmonary disease;
• Neurological disorders;
• Cardiovascular disease.

Sponsors & Collaborators

• Universidade Estadual Paulista Júlio de Mesquita Filho: lead

Study Sites (1)

Laís Manata Vanzella

Presidente Prudente, São Paulo, 19.060-900, Brazil

Location

Related Publications (1)

• Vanzella LM, Linares SN, Miranda RAT, Silva AKFD, Christofaro DGD, Netto Junior J, Vanderlei LCM. Effects of a new approach of aerobic interval training on cardiac autonomic modulation and cardiovascular parameters of metabolic syndrome subjects. Arch Endocrinol Metab. 2019 Mar-Apr;63(2):148-156. doi: 10.20945/2359-3997000000111. Epub 2019 Mar 21.

  PMID: 30916161 DERIVED

MeSH Terms

Conditions

Metabolic Syndrome; Motor Activity

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Behavior

Study Officials

• Luiz Carlos M Vanderlei, PHD

  Universidade Estadual Paulista - UNESP campus de Presidente Prudente

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Master Degree Student

Study Record Dates

• First Submitted: April 7, 2017
• First Posted: April 18, 2017
• Study Start: June 1, 2015
• Primary Completion: December 1, 2016
• Study Completion: December 1, 2016
• Last Updated: April 18, 2017

Record last verified: 2017-04

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)