Positron Emission Tomography Imaging of Brain Reorganisation of the Central Auditory Cortex in Asymetrical Profound Deaf Patient With a Cochlear Implantation.

NCT03117413 | Completed

• 2 other identifiers: RC31/15/77972016-A01442-49
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 2

Brief Summary

Our main objective is to study how the extent of reorganization of the central auditory system is related to the binaural integration in cochlear implanted subjects with asymmetric hearing loss. Subjects with asymmetric hearing loss treated with a cochlear implant and a control group of normal hearing subjects will perform two tests for binaural integration (speech recognition in noise and spatial localization) and two tasks of non-linguistic sounds perception.

Conditions

Profound Hearing Impairment

Keywords

Cochlear implantation; Deafness; Auditory cortex; Auditory plasticity; Tinnitus

Outcome Measures

Primary Outcomes (1)

• Differences in auditory brain activation between cochlear implanted asymmetric hearing loss subjects and normal hearing subjects in the binaural condition.

  Prior to the imaging session, patients performed two human voice interpretation tests. link between temporal activations and performances obtained in binaural integration tasks in the patient group.

  Day 1

Secondary Outcomes (4)

• differences in auditory brain activation.

  Week 3 - Week 5

• Performance level and the pattern of brain activation.

  Week 3 - Week 5

• the asymmetry in auditory brain activation for asymmetric hearing loss cochlear implanted subjects.

  Week 3 - Week 5

• link between binaural hearing performances and auditory brain activation in the binaural condition.

  Week 3 - Week 5

Study Arms (2)

Asymmetric hearing loss

OTHER

Asymmetric hearing loss treated with a cochlear implant will undergo positron emission tomography scan.

Other: Positron emission tomography scan

Normal hearing subjects

OTHER

Normal hearing subjects will undergo positron emission tomography scan.

Other: Positron emission tomography scan

Interventions

Positron emission tomography scan OTHER

* Binaural hearing assessments: speech recognition in noise and sound source localization * Voice perception assessment: voice/non-voice discrimination task, free categorization task * Positron emission tomography examinations under ecological auditory stimuli (voice/non-voice discrimination task)

Asymmetric hearing loss; Normal hearing subjects

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• cochlear implantation\>3 months
• signature of informed consent
• affiliation to social service.

You may not qualify if:

• associated neurological disorder
• protected subjects
• epilepsy episodes
• psychotropic medication
• pregnancy

Sponsors & Collaborators

• University Hospital, Toulouse: lead
• Centre de recherche Cerveau et Cognition (CERCO): collaborator

Study Sites (2)

CHU de Toulouse - Hôpital Purpan

Toulouse, France, 31059, France

Location

CERCO

Toulouse, Midi-Pyrénées, 31052, France

Location

Related Publications (4)

• Karoui C, Strelnikov K, Payoux P, Salabert AS, James CJ, Deguine O, Barone P, Marx M. Auditory cortical plasticity after cochlear implantation in asymmetric hearing loss is related to spatial hearing: a PET H215O study. Cereb Cortex. 2023 Feb 20;33(5):2229-2244. doi: 10.1093/cercor/bhac204.

  PMID: 35640270 RESULT

• Karoui C, James C, Barone P, Bakhos D, Marx M, Macherey O. Searching for the Sound of a Cochlear Implant: Evaluation of Different Vocoder Parameters by Cochlear Implant Users With Single-Sided Deafness. Trends Hear. 2019 Jan-Dec;23:2331216519866029. doi: 10.1177/2331216519866029.

  PMID: 31533581 RESULT

• Berland A, Collett E, Gaillard P, Guidetti M, Strelnikov K, Cochard N, Barone P, Deguine O. Categorization of everyday sounds by cochlear implanted children. Sci Rep. 2019 Mar 5;9(1):3532. doi: 10.1038/s41598-019-39991-9.

  PMID: 30837546 RESULT

• Strelnikov K, Collett E, Gaillard P, Truy E, Deguine O, Marx M, Barone P. Categorisation of natural sounds at different stages of auditory recovery in cochlear implant adult deaf patients. Hear Res. 2018 Sep;367:182-194. doi: 10.1016/j.heares.2018.06.006. Epub 2018 Jun 12.

  PMID: 29914727 RESULT

MeSH Terms

Conditions

Deafness; Tinnitus

Interventions

Magnetic Resonance Spectroscopy

Condition Hierarchy (Ancestors)

Hearing Loss; Hearing Disorders; Ear Diseases; Otorhinolaryngologic Diseases; Sensation Disorders; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Spectrum Analysis; Chemistry Techniques, Analytical; Investigative Techniques

Study Officials

• Mathieu Marx, Pr

  University Hospital, Toulouse

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Subjects with asymmetric hearing loss treated with a cochlear implant and a control group of normal hearing subjects

Study Record Dates

• First Submitted: March 10, 2017
• First Posted: April 18, 2017
• Study Start: November 23, 2017
• Primary Completion: March 22, 2019
• Study Completion: March 22, 2019
• Last Updated: May 6, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

FR (2)