NCT03113630

Brief Summary

Thirty individuals with ALS (18 men and 12 women, mean age 59 years, range 44-74 years), and 30 healthy controls matched for age and gender, participated. Individuals with ALS and from the control group were randomly divided into three groups, each using a different communication device systems (Kinect®, Leap Motion Controller® or touchscreen) to perform two task phases (acquisition and retention). Performance was then explored in a third phase (transfer) by switching devices (two transfers); so that, all groups had contact with all communication interfaces.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
60

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Feb 2016

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 2, 2016

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 3, 2016

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

October 4, 2016

Completed
6 months until next milestone

First Submitted

Initial submission to the registry

April 2, 2017

Completed
11 days until next milestone

First Posted

Study publicly available on registry

April 13, 2017

Completed
Last Updated

April 13, 2017

Status Verified

April 1, 2017

Enrollment Period

6 months

First QC Date

April 2, 2017

Last Update Submit

April 8, 2017

Conditions

Keywords

Amyotrophic Lateral SclerosisVirtual Reality Exposure TherapyUser-Computer InterfaceRehabilitationMotor Activity

Outcome Measures

Primary Outcomes (1)

  • Motor performance improvement in a virtual Timing Coincident task, comparing performance between LeapMotion, TouchScreen and Kinect.

    Analysis of the motor performance using a virtual Coincident timing task in different devices to compare wether a task with or without contact promote better performance for people with Amyotrophic Lateral Sclerosis

    3 months

Study Arms (6)

Acquisition on TouchScreen

EXPERIMENTAL

Subjects practice the task and retention TouchScreen, transfer 1 on LeapMotion and transfer 2 on Kinect

Device: Acquisition on TouchScreen

Acquisition on Kinect

EXPERIMENTAL

Subjects practice the task and retention Kinect, transfer 1 on TouchScreen and transfer 2 on LeapMotion.

Device: Acquisition on Kinect

Acquisition on LeapMotion

EXPERIMENTAL

Subjects practice the task and retention LeapMotion, transfer 1 on TouchScreen and transfer 2 on Kinect.

Device: Acquisition on LeapMotion

Acquisition on TouchScreen Control Group

ACTIVE COMPARATOR

Subjects practice the task and retention TouchScreen, transfer 1 on LeapMotion and transfer 2 on Kinect

Device: Acquisition on TouchScreen Control Group

Acquisition on Kinect Control Group

ACTIVE COMPARATOR

Subjects practice the task and retention Kinect, transfer 1 on TouchScreen and transfer 2 on LeapMotion.

Device: Acquisition on Kinect Control Group

Acquisition on LeapMotion Control Group

ACTIVE COMPARATOR

Subjects practice the task and retention LeapMotion, transfer 1 on TouchScreen and transfer 2 on Kinect.

Device: Acquisition on LeapMotion Control Group

Interventions

Participants performed acquisition and retention on TouchScreen, transfer 1 on Kinect and transfer 2 on LeapMotion.

Acquisition on TouchScreen

Participants performed acquisition and retention on Kinect, transfer 1 on TouchScreen and transfer 2 on LeapMotion.

Acquisition on Kinect

Participants performed acquisition and retention on LeapMotion, transfer 1 on TouchScreen and transfer 2 on Kinect.

Acquisition on LeapMotion

Participants performed acquisition and retention on TouchScreen, transfer 1 on Kinect and transfer 2 on LeapMotion.

Acquisition on TouchScreen Control Group

Participants performed acquisition and retention on Kinect, transfer 1 on TouchScreen and transfer 2 on LeapMotion.

Acquisition on Kinect Control Group

Participants performed acquisition and retention on LeapMotion, transfer 1 on TouchScreen and transfer 2 on Kinect.

Acquisition on LeapMotion Control Group

Eligibility Criteria

Age40 Years - 75 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • individuals diagnosed with ALS defined according to the revised classification of El Escorial;
  • individuals who regularly attended the Neuromuscular Disease Research Sector (SIDNM) of the Federal University of São Paulo

You may not qualify if:

  • individuals who had other diagnosis of neuromuscular disease such as: progressive muscular atrophy (PMA), progressive bulbar paralysis (PBP), primary lateral sclerosis (PLS);
  • individuals associated with other neurodegenerative diseases;
  • those presenting established functional disability that would prevent the completion of the task.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Escola de Artes,Ciencias e Humanidades da Universidade d Sao Paulo

São Paulo, São Paulo, 03828-000, Brazil

Location

Related Publications (1)

  • Trevizan IL, Silva TD, Dawes H, Massetti T, Crocetta TB, Favero FM, Oliveira ASB, de Araujo LV, Santos ACC, de Abreu LC, Coe S, Monteiro CBM. Efficacy of different interaction devices using non-immersive virtual tasks in individuals with Amyotrophic Lateral Sclerosis: a cross-sectional randomized trial. BMC Neurol. 2018 Dec 17;18(1):209. doi: 10.1186/s12883-018-1212-3.

MeSH Terms

Conditions

Amyotrophic Lateral SclerosisMotor Activity

Condition Hierarchy (Ancestors)

Spinal Cord DiseasesCentral Nervous System DiseasesNervous System DiseasesMotor Neuron DiseaseNeurodegenerative DiseasesTDP-43 ProteinopathiesNeuromuscular DiseasesProteostasis DeficienciesMetabolic DiseasesNutritional and Metabolic DiseasesBehavior

Study Officials

  • Carlos BM Monteiro, Ph.D.

    University of Sao Paulo

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

April 2, 2017

First Posted

April 13, 2017

Study Start

February 2, 2016

Primary Completion

August 3, 2016

Study Completion

October 4, 2016

Last Updated

April 13, 2017

Record last verified: 2017-04

Locations