The Effects of Capsinoids on Brown Adipose Tissue Activation in Obesity

NCT03110809 | Completed

• 1 other identifier: SP0037287
• Study Type: interventional
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

This research study is being done to determine whether taking a dietary supplement called capsinoids, derived from sweet peppers, can activate brown fat that is already present or even generate new brown fat in individuals with excess weight. Previous studies have suggested that chronic consumption of capsinoids may be able to generate new brown fat in thin individuals. Capsinoids may also have a small positive effect on metabolism (increased calorie-burning) and fat loss. The knowledge gained in this study may eventually lead to more treatment options for people with excess weight.

Conditions

Weight Loss

Keywords

obesity; brown; fat; weight; loss

Outcome Measures

Primary Outcomes (1)

• MRI BAT activity maps

  Develop multi-parametric MRI BAT activity maps by comparing MRI measurements at thermo-neutral, non-shivering thermogenesis and warm-up conditions.

  22 weeks

Study Arms (4)

BAT Positive Placebo

PLACEBO COMPARATOR

Participants will be confirmed positive for BAT activity, but on Placebo

Dietary Supplement: Placebo

BAT Negative Placebo

PLACEBO COMPARATOR

Participants will be confirmed negative for BAT activity, but on Placebo

Dietary Supplement: Placebo

BAT Positive Capsinoid

EXPERIMENTAL

Participants will be confirmed positive for BAT activity, but taking Capsinoids. Capsinoids are a derivative of sweet peppers that may activate and recruit BAT.

Dietary Supplement: Capsinoid

BAT Negative Capsinoid

EXPERIMENTAL

Participants will be confirmed negative for BAT activity, but taking Capsinoids. Capsinoids are a derivative of sweet peppers that may activate and recruit BAT.

Dietary Supplement: Capsinoid

Interventions

Capsinoid DIETARY_SUPPLEMENT

Capsinoids are nunpungent analogs of capsaicin that activate BAT by stimulating sensory neurons in the gastrointestinal tract. Chronic ingestion of capsinoids may stimulate the development or recruitment of new BAT from precursor stem cells within white adipose tissue depots.

BAT Negative Capsinoid; BAT Positive Capsinoid

Placebo DIETARY_SUPPLEMENT

Placebo for capsinoid. Capsule contains no active ingredients.

BAT Negative Placebo; BAT Positive Placebo

Eligibility Criteria

• Age: 18 Years - 50 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male.
• years old.
• Non-smoking.
• Overweight/Obese (BMI 27-45).
• Generally healthy.

Sponsors & Collaborators

• Northwestern University: lead

Study Sites (1)

Northwestern University

Chicago, Illinois, 60611, United States

Location

MeSH Terms

Conditions

Weight Loss; Obesity; Platelet Glycoprotein IV Deficiency; Body Weight

Condition Hierarchy (Ancestors)

Body Weight Changes; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases

Study Officials

• Lisa M Neff, MD., MS.

  Northwestern University Feinberg School of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Study Record Dates

• First Submitted: March 20, 2017
• First Posted: April 12, 2017
• Study Start: April 17, 2017
• Primary Completion: August 13, 2021
• Study Completion: August 13, 2021
• Last Updated: December 14, 2021

Record last verified: 2021-12

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)