Progenitor Cells in Human Esophagus
1 other identifier
observational
10
1 country
1
Brief Summary
The purpose of this study is to better understand how esophageal cells change with age.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Jun 2017
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
April 6, 2017
CompletedFirst Posted
Study publicly available on registry
April 11, 2017
CompletedStudy Start
First participant enrolled
June 29, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 22, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
November 22, 2022
CompletedDecember 5, 2022
December 1, 2022
5.4 years
April 6, 2017
December 1, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Amount of Progenitor Cells
We will examine sections of different portions of the esophagus, to determine whether certain sections contain more progenitors, and thus perhaps a greater ability to regenerate, than others.
1 year
Eligibility Criteria
Adults undergoing esophageal surgery at Mayo Clinic Rochester
You may qualify if:
- ≥ 18 years old
- Esophagus surgery at Mayo Clinic
You may not qualify if:
- \<18 years old
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Mayo Cliniclead
Study Sites (1)
Mayo Clinic
Rochester, Minnesota, 99509, United States
Related Links
Biospecimen
Esophageal tissue will be collected at the time of the patient's surgery in excess of clinical diagnosis (i.e. tissue that would otherwise be discarded). The researchers will analyze sections of adult esophagus tissue for the presence of CD34+ sox2+ progenitor cells to determine the number of progenitors present at a particular age of patient. The researchers will also examine sections of different portions of the esophagus, to determine whether certain sections contain more progenitors, and thus perhaps a greater ability to regenerate, than others.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Dennis Wigle, MD, PhD
Mayo Clinic
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- MD, PhD
Study Record Dates
First Submitted
April 6, 2017
First Posted
April 11, 2017
Study Start
June 29, 2017
Primary Completion
November 22, 2022
Study Completion
November 22, 2022
Last Updated
December 5, 2022
Record last verified: 2022-12
Data Sharing
- IPD Sharing
- Will not share