National Early Warning Score and D-dimer to Identify Medical Patients At Low Risk of 30-day Mortality

NCT03108807 | Completed DMC

• 1 other identifier: S-20170005
• Study Type: observational
• Target: 1,700
• Locations: 1 country
• Sites: 1

Brief Summary

The aim is to determine if the National Early Warning Score combined with plasma D-dimer levels can be used in risk stratification of acutely ill medical patients presenting to a Danish Emergency Department. The investigators wish to identify patients at low risk of mortality within 30 days.

Conditions

Medical Patients in the Emergency Department

Keywords

Emergency Department; Medical patients; D-dimer; National Early Warning Score; NEWS; 30-days mortality; Mortality

Outcome Measures

Primary Outcomes (1)

• 30-days mortality

  mortality within 30 days after assessment will be determined for all patients using data extracted from the Danish Civil Registration System patients using data extracted from the Danish Civil Registration System

  30 days

Secondary Outcomes (2)

• Hospital length of stay (LOS)

  30 days

• Readmissions within 30 days

  30 days

Interventions

D-dimer test DIAGNOSTIC_TEST

D-dimer test

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

An unselected group of consecutive patients in a Danish Emergency Department.

You may qualify if:

• Admission to the Emergency Department of Hospital of South West Jutland
• Requirement of any blood test
• Age 18 years
• Informed consent given

You may not qualify if:

• Age 18 years
• Informed consent not given

Sponsors & Collaborators

• Esbjerg Hospital - University Hospital of Southern Denmark: lead
• University of Southern Denmark: collaborator

Study Sites (1)

Hospital of South West Jutland

Esbjerg, 6700, Denmark

Location

Related Publications (3)

• Nickel CH, Kuster T, Keil C, Messmer AS, Geigy N, Bingisser R. Risk stratification using D-dimers in patients presenting to the emergency department with nonspecific complaints. Eur J Intern Med. 2016 Jun;31:20-4. doi: 10.1016/j.ejim.2016.03.006. Epub 2016 Apr 1.

  PMID: 27053291 BACKGROUND

• Nickel CH, Kellett J, Cooksley T, Bingisser R, Henriksen DP, Brabrand M. Combined use of the National Early Warning Score and D-dimer levels to predict 30-day and 365-day mortality in medical patients. Resuscitation. 2016 Sep;106:49-52. doi: 10.1016/j.resuscitation.2016.06.012. Epub 2016 Jun 20.

  PMID: 27339095 BACKGROUND

• Nickel CH, Kellett J, Nieves Ortega R, Lyngholm L, Wasingya-Kasereka L, Brabrand M. Mobility Identifies Acutely Ill Patients at Low Risk of In-Hospital Mortality: A Prospective Multicenter Study. Chest. 2019 Aug;156(2):316-322. doi: 10.1016/j.chest.2019.04.001. Epub 2019 Apr 11.

  PMID: 30981722 DERIVED

MeSH Terms

Conditions

Emergencies

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Mikkel Brabrand, MD, PhD

  Esbjerg Hospital - University Hospital of Southern Denmark

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD, clinical associate professor

Study Record Dates

• First Submitted: April 3, 2017
• First Posted: April 11, 2017
• Study Start: April 24, 2017
• Primary Completion: August 19, 2017
• Study Completion: August 19, 2017
• Last Updated: September 19, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)