The Effect of Norepinephrine Versus Dopamine in Renal Transplant Recipients on Postoperative Graft Function
1 other identifier
interventional
44
1 country
1
Brief Summary
Renal transplantation is now recognized as a treatment of choice for patients with chronic renal failure with end-stage renal disease. Renal transplantations are associated with better quality of life, better cost/benefit ratio, and possibly longer survival. Significant changes in blood pressure are common throughout the surgical procedure for kidney transplantation. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration. All efforts are made to maintain an appropriate level of blood pressure by using an adequate intravascular volume and vasopressor administration.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_2
Started Nov 2017
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 24, 2017
CompletedFirst Posted
Study publicly available on registry
April 11, 2017
CompletedStudy Start
First participant enrolled
November 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2019
CompletedOctober 20, 2017
October 1, 2017
1.2 years
March 24, 2017
October 18, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
serum creatinine
postoperative
four hours postoperatively
Secondary Outcomes (4)
blood urea
four hours postoperatively
urine output
over 24 hours
renal artery diameter
four hours postoperatively
renal artery blood flow
four hours postoperatively
Study Arms (2)
Norepinephrine
ACTIVE COMPARATORDopamine
ACTIVE COMPARATORInterventions
Norepinephrine infusion will be used at a starting dose of 0.05μg/kg/min. Dose range: 0.05 -0.15 μg/kg/min. Infusion will be started with arterial decamping and continues till 24 hours postoperative
Dopamine infusion will be used at a starting dose of 5μg/kg/min. Dose range: 5 -15 μg/kg/min. Infusion will be started with arterial decamping and continues till 24 hours postoperative
Eligibility Criteria
You may qualify if:
- Patients scheduled for a living donor kidney transplantation
You may not qualify if:
- Patients (less than 18 years old)
- Patients' refusal of consenting for enrolment in the study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Assiut University Hospital
Asyut, 71515, Egypt
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 2
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Specialist
Study Record Dates
First Submitted
March 24, 2017
First Posted
April 11, 2017
Study Start
November 1, 2017
Primary Completion
January 1, 2019
Study Completion
November 1, 2019
Last Updated
October 20, 2017
Record last verified: 2017-10