Tongji Maternal and Child Health Cohort

NCT03099837 | Unknown

• 1 other identifier: HuazhongU-2013-02
• Study Type: observational
• Target: 8,649
• Locations: 0 countries
• Sites: N/A

Brief Summary

This is a population-based study to obtain data for the evaluation of current used recommendations for weight gain during pregnancy released by IOM (2007) and investigate the association between maternal diet and the health outcomes of mother and offspring.

Conditions

Weight Gain; Maternal; Diabetes Mellitus, Affecting Fetus; Diet Habit; Pregnancy Complications; Birth Outcomes; Breast Feeding; Growth and Development

Outcome Measures

Primary Outcomes (3)

• Effect of weight gain during pregnancy on maternal and child health

  To regularly measure the weight gains of pregnant women during pregnancy, and examine their association with maternal and child health.

  During pregnancy, infancy period and childhood, assessed up to 120 months

• Effect of factors in pregnancy and early postpartum period on maternal health

  To examine the role of maternal nutrition, lifestyle, emotional health, and other environmental factors in pregnancy or postpartum period that can influence future maternal risk of metabolic disorders and even lead to complications of pregnancy, such as gestational diabetes mellitus.

  During pregnancy and postpartum period, assessed up to 12 months

• Influence of prenatal and early postnatal factors on child health

  To examine the role of maternal nutrition, lifestyle, emotional health, breastfeeding, and other environmental factors in infancy that can influence the development of phenotypes in childhood which confer risk for later metabolic and mental disorders.

  During pregnancy, infancy period and childhood, assessed up to 120 months

Study Arms (3)

Pregnant mothers

infants

children

Eligibility Criteria

• Sex: female
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The Tongji Maternal and Child Health enrolled healthy pregnant women at 8-16 weeks gestation when they attended their first antenatal visit at a maternity clinic in one of these following hospitals in Wuhan, China: Hubei Maternal and Child Health Hospital (HMCHH), The Central Hospital of Wuhan(CHW), Wuhan Maternal and Child Health Hospital (WMCHH), Jiang'an Maternal and Child Health Hospital(JMCHH). Babies born from these mothers will be followed up until the child is at least 10 years of age.

You may qualify if:

• Pregnant women attending the first visit (\<16 weeks ) at at a maternity clinic in one of these following hospitals in Wuhan, China: HMCHH, CHW,WMCHH,JMCHH.
• Intention to visit the maternity clinic regularly in HMCHH or CHW or WMCHH or JMCHH.
• Intention to eventually deliver in HMCHH or CHW or WMCHH.
• The pregnant woman and her husband are Chinese.

You may not qualify if:

• Pregnant women on chemotherapy.
• Exclude women on certain medications - e.g. psychotropic drugs.
• Exclude women with significant medical conditions e.g. psychosis etc.

Sponsors & Collaborators

• Huazhong University of Science and Technology: lead
• Maternal and Child Health Hospital of Hubei Province: collaborator
• Wuhan Central Hospital: collaborator
• Wuhan Maternal and Child Health Hospital: collaborator

Related Publications (6)

• Kong M, Zhong C, Gao Q, Zhou X, Chen R, Xiong G, Hao L, Yang X, Lu Z, Yang N. Association of elevated mid-pregnancy maternal plasma ferritin concentrations and triglyceride concentrations with the risk of gestational diabetes mellitus: A prospective cohort study. Diabetes Metab Res Rev. 2023 Sep;39(6):e3637. doi: 10.1002/dmrr.3637. Epub 2023 Apr 13.

  PMID: 36958940 DERIVED

• Zhong C, Xiong G, Lin L, Li Q, Chen X, Zhang X, Zhang Y, Xu S, Wang X, Gao D, Wu M, Yang S, Han W, Sun G, Yang X, Hao L, Jin Z, Yang N. The association of maternal vaginal bleeding and progesterone supplementation in early pregnancy with offspring outcomes: a prospective cohort study. BMC Pregnancy Childbirth. 2022 May 5;22(1):390. doi: 10.1186/s12884-022-04711-1.

  PMID: 35513779 DERIVED

• Li Y, Zhou X, Zhang Y, Zhong C, Huang L, Chen X, Chen R, Wu J, Li Q, Sun G, Yin H, Xiong G, Hao L, Yang N, Yang X. Association of Maternal Dietary Patterns With Birth Weight and the Mediation of Gestational Weight Gain: A Prospective Birth Cohort. Front Nutr. 2021 Nov 26;8:782011. doi: 10.3389/fnut.2021.782011. eCollection 2021.

  PMID: 34901129 DERIVED

• Xiong T, Wu Y, Huang L, Chen X, Zhang Y, Zhong C, Gao Q, Hong M, Hu X, Yang X, Yang N, Hao L. Association of the maternal serum albumin level with fetal growth and fetal growth restriction in term-born singletons: a prospective cohort study. Fertil Steril. 2022 Feb;117(2):368-375. doi: 10.1016/j.fertnstert.2021.09.016. Epub 2021 Oct 20.

  PMID: 34686372 DERIVED

• Gao Q, Zhong C, Zhou X, Chen R, Xiong T, Hong M, Li Q, Kong M, Xiong G, Han W, Sun G, Yang X, Yang N, Hao L. Inverse association of total polyphenols and flavonoids intake and the intake from fruits with the risk of gestational diabetes mellitus: A prospective cohort study. Clin Nutr. 2021 Feb;40(2):550-559. doi: 10.1016/j.clnu.2020.05.053. Epub 2020 Jun 13.

  PMID: 32593522 DERIVED

• Zhou X, Chen R, Zhong C, Wu J, Li X, Li Q, Cui W, Yi N, Xiao M, Yin H, Xiong G, Han W, Hao L, Yang X, Yang N. Fresh fruit intake in pregnancy and association with gestational diabetes mellitus: A prospective cohort study. Nutrition. 2019 Apr;60:129-135. doi: 10.1016/j.nut.2018.09.022. Epub 2018 Oct 24.

  PMID: 30572275 DERIVED

MeSH Terms

Conditions

Weight Gain; Diabetes Mellitus; Feeding Behavior; Pregnancy Complications; Breast Feeding

Condition Hierarchy (Ancestors)

Body Weight Changes; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Behavior, Animal; Behavior; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 17, 2017
• First Posted: April 4, 2017
• Study Start: January 10, 2013
• Primary Completion: January 10, 2023
• Study Completion: January 10, 2023
• Last Updated: August 4, 2020

Record last verified: 2020-08

Data Sharing

• IPD Sharing: Will not share