Nanoparticles Emitted by Aircraft Engines, Impact on Respiratory Function

NCT03098784 | Completed DMC

• 2 other identifiers: 87552011-A00646-35
• Study Type: observational
• Target: 472
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this study is to assess the respiratory health of the Air France company's employees working in the Marseilles and Paris airports (flight line and administrative employees). This study was promoted by the Montpellier CHRU, Regional University Hospital Centre (ANSM identification number 2011-A00646-35). It allowes voluntary employees to be involved. They answer a lifestyle survey and perform a spirometry, an exhaled CO measurement and a sampling of exhaled air condensate (EAC). A metrological study of particles emitted by aircraft engines and found in the airport environment will be conducted and the elementary chemical composition analysis, as well a sieve analysis of particles present in the EAC will be conducted.

Conditions

Respiratory Function

Keywords

airport environment; Air France; flightline employees; administrative employees

Outcome Measures

Primary Outcomes (1)

• The quantity of nanoparticules present in exhaled air condensate

  The quantity of nanoparticules present in exhaled air condensate

  1 day (Day of inclusion (D0)

Secondary Outcomes (6)

• Exhaled CO measurement

  1 day (Day of inclusion (D0)

• Exhaled NO measurement

  1 day (Day of inclusion (D0)

• Exhaled air condensate

  1 day (Day of inclusion (D0)

• oxidative stress marker (8 isoprostane)

  1 day (Day of inclusion (D0)

• plasma mass spectrometry which allows the simultaneous assaying of 17 elements

  1 day (Day of inclusion (D0)

Study Arms (2)

Air France employees working near runways

Air France personnel mainly working in physical proximity to the runways of the Marseille Marignane or Parisian airports. Intervention: Exposure to aircraft exhaust

Other: Exposure to aircraft exhaust

Air France employees working inside

Air France personnel working mainly inside buildings at the Marseille Marignane or Parisian airports. Intervention: Non exposure to aircraft exhaust

Other: Non exposure to aircraft exhaust

Interventions

Exposure to aircraft exhaust OTHER

The exposed group is made up of Air France personnel mainly working in physical proximity to the runways of the Marseille Marignane or Parisian airports. These people are subject to direct exposure to exhaust from aircraft engines.

Air France employees working near runways

Non exposure to aircraft exhaust OTHER

The non-exposed group is made up of Air France personnel working mainly inside buildings at the Marseille Marignane or Parisian airports. These people are not subject to direct exposure to exhaust from aircraft engines.

Air France employees working inside

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Air France employees working in the Marseilles or Parisian airports (flightline and administrative employees)

You may qualify if:

• Subject must be given free and informed consent and signed the consent
• Subject must be affiliated or beneficiary in a health insurance plan

You may not qualify if:

• Subject has a cons-indication (or an incompatible combination therapy) for the realization of the EFR

Sponsors & Collaborators

• University Hospital, Montpellier: lead
• Aix Marseille Université: collaborator
• LBM- Nanosecurity platform - CEA Grenoble: collaborator
• LR2N - Nanosecurity platform - CEA Grenoble: collaborator

MeSH Terms

Conditions

Respiratory Aspiration

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• NICOLAS MOLINARI

  University Hospital, Montpellier

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 23, 2016
• First Posted: April 4, 2017
• Study Start: November 1, 2011
• Primary Completion: June 1, 2012
• Study Completion: June 1, 2012
• Last Updated: April 4, 2017

Record last verified: 2017-03

Data Sharing

• IPD Sharing: Will share