NCT03097042

Brief Summary

The embryologist will oad the embryos into the catheter at the right position, then the catheter will be slowly pushed through the cervical canal, 1-2 cm beneath the fundus 5.5 cm away from the cervical external os.The embryos will be delivered by pushing the plunger of the syringe from the mid-cavitary positioned catheter and keeping the plunger pushed down. Study Group: The catheter will be pulled back slowly and without rotation with the plunger still pushed forward. Control Group: The catheter will be pulled back slowly with a 360°rotation with the plunger kept pushed forward.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
200

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Feb 2017

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 24, 2017

Completed
8 days until next milestone

Study Start

First participant enrolled

February 1, 2017

Completed
2 months until next milestone

First Posted

Study publicly available on registry

March 31, 2017

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2017

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

August 31, 2017

Completed
Last Updated

January 31, 2018

Status Verified

January 1, 2018

Enrollment Period

6 months

First QC Date

January 24, 2017

Last Update Submit

January 29, 2018

Conditions

Outcome Measures

Primary Outcomes (1)

  • Clinical Pregnancy

    Detection of the fetal heart rate by ultrasonography

    6 months

Secondary Outcomes (1)

  • mucus or blood stained catheter

    6 months

Study Arms (2)

Study group

ACTIVE COMPARATOR

The catheter will be pulled back slowly and without rotation

Procedure: Embryo transfer with catheter Manipulation

Control Group

ACTIVE COMPARATOR

The catheter will be pulled back by rotating 360 degrees round itself

Procedure: Embryo transfer any further manipulation

Interventions

The catheter will be pulled back slowly and without rotation with the plunger still pushed forward

Control Group

catheter rotation during withdrawal

Study group

Eligibility Criteria

Age20 Years - 40 Years
Sexfemale(Gender-based eligibility)
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Volunteers between the ages 20 to 40 Good quality embryo transfer Easy embryo transfer (use of soft catheter, not using tenaculum), Fresh cycle Single embryo transfer

You may not qualify if:

  • Volunteers younger than 20 and older than 40 years old Volunteers with poor ovarian reserve Low quality embryos Difficult embryo transfer (use of rigid catheter, use of tenaculum, passing of outer catheters heath from cervical os) Frozen cycle Volunteers that receive another transfer of embryos that remain in the catheter after the initial transfer.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Zeynep Kamil Hospital

Istanbul, Turkey (Türkiye)

Location

Related Publications (1)

  • Yayla Abide C, Ozkaya E, Sanverdi I, Bostanci Ergen E, Kurek Eken M, Devranoglu B, Bilgic BE, Kilicci C, Kayatas Eser S. Prospective Randomized Trial Comparing Embryo Transfers of Cases with and without Catheter Rotation during Its Withdrawal. Gynecol Obstet Invest. 2018;83(4):397-403. doi: 10.1159/000489493. Epub 2018 May 14.

MeSH Terms

Interventions

Embryo Transfer

Intervention Hierarchy (Ancestors)

Reproductive Techniques, AssistedReproductive TechniquesTherapeuticsInvestigative Techniques

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Randomized Controlled Trial
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD

Study Record Dates

First Submitted

January 24, 2017

First Posted

March 31, 2017

Study Start

February 1, 2017

Primary Completion

August 1, 2017

Study Completion

August 31, 2017

Last Updated

January 31, 2018

Record last verified: 2018-01

Locations