Hepatopulmonary Syndrome and Postoperative Complications After Liver Transplantation : A Case-control Study

NCT03092401 | Unknown

• 1 other identifier: 69HCL17_0210
• Study Type: observational
• Target: 142
• Locations: 0 countries
• Sites: N/A

Brief Summary

Hepatopulmonary Syndrome is a respiratory complication of liver cirrhosis defined as a triad: hypoxemia (PaO2 \< 80 mmHg in room air), chronic liver disease and intrapulmonary vasodilatations. Its prevalence varies between 4 and 32%. Numerous treatments have been tried but the only efficient therapy to cure the syndrome is liver transplantation. Without transplantation it is associated with a higher mortality which is the reason why hepatopulmonary syndrome patients have a higher priority to transplantation. However it appears in some restricted studies that hepatopulmonary syndrome is associated with more postoperative complications (infections, vascular and biliary complications, prolonged length of mechanical ventilation…). The investigators hypothesised that hepatopulmonary syndrome patients have more postoperative complications after liver transplantation than non hepatopulmonary syndrome patients matched on age, MELD (Model for End-Stage Liver Disease) score, comorbidities, perioperative transfusion and noradrenaline doses.

Conditions

Hepatopulmonary Syndrome; Liver Cirrhosis

Keywords

Liver transplantation; Hepatopulmonary Syndrome; Liver Cirrhosis

Outcome Measures

Primary Outcomes (1)

• Postoperative complication rates in hepatic transplant patients with or without hepatopulmonary syndrome

  Collection of medical (cardiac, pulmonary, renal, infectious, neurological) and Surgical (vascular, digestive) complications in hepatic transplant patients with or without hepatopulmonary syndrome

  1 year post liver transplantation

Secondary Outcomes (4)

• Length of Mechanical Ventilation

  1 year post liver transplantation

• Length of ICU stay

  1 year post liver transplantation

• Length of Hospital Stay

  1 year post liver transplantation

• Delay of hepatopulmonary syndrome resolution

  1 year post liver transplantation

Study Arms (2)

hepatic transplant patients with hepatopulmonary syndrome

hepatic transplant patients without hepatopulmonary syndrome

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who underwent liver transplantation between 2010 and 2016

You may qualify if:

• Liver transplanted patients

You may not qualify if:

• Living donor transplantation
• Bipartition transplantation
• Non-heat-beating donor transplantation
• Minor
• Double or multiple organ transplantation
• Non cirrhotic patients
• Retransplantation

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

MeSH Terms

Conditions

Hepatopulmonary Syndrome; Liver Cirrhosis

Condition Hierarchy (Ancestors)

Liver Diseases; Digestive System Diseases; Lung Diseases; Respiratory Tract Diseases; Fibrosis; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 20, 2017
• First Posted: March 27, 2017
• Study Start: October 1, 2015
• Primary Completion: March 31, 2017
• Study Completion: March 31, 2017
• Last Updated: March 28, 2017

Record last verified: 2017-03