Bioavailability Study of BIA 5-453

You may not qualify if:

• had a clinically relevant history or presence of respiratory, gastrointestinal, renal, hepatic, haematological, lymphatic, neurological, cardiovascular, psychiatric, musculoskeletal, genitourinary, immunological, dermatological, endocrine, connective tissue diseases or disorders.
• had a clinically relevant surgical history.
• had a clinically relevant family history.
• had a history of relevant atopy or drug hypersensitivity.
• had a history of alcoholism or drug abuse.
• consumed more than 14 units of alcohol a week.
• had a significant infection or known inflammatory process at screening or admission to the first treatment period.
• had acute gastrointestinal symptoms (e.g., nausea, vomiting, diarrhoea, heartburn) at the time of screening or admission to the first treatment period.
• used medicines within 2 weeks of admission to first period that affected the safety or other study assessments, in the investigator's opinion.
• used any investigational drug or participated in any clinical trial within 3 months prior to screening.
• participated in more than 2 clinical trials within the 12 months prior to screening.
• donated or received any blood or blood products within the 3 months prior to screening.
• was a vegetarian, vegan or with medical dietary restrictions.
• could not communicate reliably with the investigator.
• was unlikely to co-operate with the requirements of the study.
• +1 more criteria