Intranasal Insulin for the Treatment of HAND

You may not qualify if:

• Current or past opportunistic infection of the brain,
• History or current clinical evidence of schizophrenia,
• History of chronic neurological disorder, such as multiple sclerosis or uncontrolled epilepsy,
• Active symptomatic AIDS defining opportunistic infection within 30 days prior to study entry,
• History of an uncontrolled medical or psychiatric illness which in the opinion of the investigators would constitute a safety risk for patients or interfere with the ability of a participant to complete the study,
• History of diabetes or treatment with insulin or an oral hypoglycemic agent,
• Amylase/lipase elevation (≥ 2 X upper limit of normal) within 14 days prior to starting study drug,
• Detectable plasma HIV RNA test ≥400 copies/mL within 6 months prior to baseline/randomization,
• History of any endocrine related cancer, including any thyroid tumor,
• Current use of cocaine, heroin, or methamphetamine. Current use will be defined and determined by any evidence of such use within the two years (730 days) prior to study enrollment; evidence includes but is not limited to urine drug toxicology testing by the study team at screening and pre-entry visits,
• Presence of other conditions that significantly affect and complicate performance on neurocognitive tests (such as, learning disabilities, history of severe alcohol abuse, head injury with trauma to the brain and loss of consciousness \>30 minutes).