CANON
Sponsor study identifier
interventional
192
1 country
1
Study Start
February 28, 2017
Actual (reported)Primary Completion
July 1, 2018
Actual (reported)Study Completion
July 1, 2018
Actual (reported)The objective of this study is to investigate the value of employing the aortic no-touch off-pump coronary artery bypass technique and the practice of carbon dioxide surgical field flooding for the prevention of type 1 and 2 neurological injuries following surgical coronary revascularization.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
July 1, 2018
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 28, 2017
Actual (reported)February 28, 2017
Actual (reported)March 9, 2017
Actual (reported)July 1, 2018
Actual (reported)July 1, 2018
Actual (reported)New lesions on control brain magnetic resonance imaging.
Appearance of new lesions on control brain magnetic resonance imaging 3 days after surgery.
3 days after surgery
New focal neurological deficits.
7 days after surgery
Occurence of postoperative cognitive dysfunction
1 week or 3 months after surgery
aortic no-touch OPCABG
OPCABG with partial clamp applying carbon dioxide
OPCABG with partial clamp
(Study arm 1) In this intervention only the internal mammary artery grafts will be used (i.e. left internal mammary artery graft, right internal mammary artery graft, or a Y-graft that uses right internal mammary artery graft anastomosed onto left internal mammary artery graft to allow for a wide territory of myocardial revascularization). However, in the rare event that the aforementioned approach is insufficient to reach all target vessels, a reversed (great) saphenous vein graft may be used to extend the left internal mammary artery graft or the right internal mammary artery graft.
Department of Cardiac Surgery, Dr Antoni Jurasz Memorial University Hospital
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-001, Poland
Krzysztof S, Wojciech P, Zbigniew S, Mariusz K, Remigiusz T, Damian P, Magdalena S, Marta T, Lech A, Alina B. CArbon dioxide surgical field flooding and aortic NO-touch off-pump coronary artery bypass grafting to reduce Neurological injuries after surgical coronary revascularisation (CANON): protocol for a randomised, controlled, investigator and patient blinded single-centre superiority trial with three parallel arms. BMJ Open. 2017 Jul 10;7(7):e016785. doi: 10.1136/bmjopen-2017-016785.
Krzysztof Szwed, M.D. Ph.D.
Department of Clinical Neuropsychology, Nicolaus Copernicus University, Collegium Medicum, Poland
Alina Borkowska, Professor
Department of Clinical Neuropsychology, Nicolaus Copernicus University, Collegium Medicum, Poland
192 participants (actual enrollment reported by the registry).
First Submitted
February 28, 2017
First Posted
March 9, 2017
Incidence of delirium
7 days after surgery
(Study arm 2) In this intervention chest cavity will be insufflated with carbon dioxide at a flow above 5 l/min during the entire surgical procedure.
(Study arm 3) This is the control arm undergoing "traditional" OPCABG with partial clamp.
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Study Start
February 28, 2017
Actual (reported)Primary Completion
July 1, 2018
Actual (reported)Study Completion
July 1, 2018
Actual (reported)Last Updated
February 5, 2020
Record last verified: 2020-02
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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Source: ClinicalTrials.gov.
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