Spectrometry for TIA Rapid Assessment (SpecTRA) Project: Study 2-Validation of Clinical Features and Protein Biomarkers
Sponsor study identifier
observational
1,150
1 country
2
Study Start
April 1, 2015
Actual (reported)Primary Completion
March 31, 2017
Actual (reported)Study Completion
March 31, 2017
Actual (reported)A clinical decision support rule/tool for classification of TIA/mimic that will enable rapid detection of ACVS in hyper-acute settings is being developed. Also under development is a multi-protein test using mass spectrometry (MS). This test will provide TIA results within an hour or two for a fraction of the price of neuroimaging. With guidance provided by this test at their disposal, physicians can inform patients whether they can go home safely or whether they need further testing. The right patients will receive the right treatment, reduce unwarranted imaging risks and costs, and reduce the burden of stroke. The Heart and Stroke Foundation will work to ensure that physicians, allied healthcare providers, the public and other stakeholders are aware of the outcomes and clinical impacts of this project. Further, work is being done to establish the mechanisms to develop a strong phenotype for TIA that includes medical imaging (MRI), cardiac monitoring, cognitive assessments, and surveillance of health outcomes for extended periods of time.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
March 31, 2017
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 1, 2015
Actual (reported)February 28, 2017
Actual (reported)March 3, 2017
Actual (reported)March 31, 2017
Actual (reported)March 31, 2017
Actual (reported)Validation of a Protein Classifier for the Diagnosis of TIA in the Emergency Department
Calculated score for distinguishing ACVS from Mimic based on previously locked-down formula involving 16 proteins measured using multiple reaction monitoring in blood samples taken within 24 hours from onset of symptoms.
24 Hours
The Validation of a Clinical Classifier for the Diagnosis of TIA in the Emergency Department.
24 hours
Clinical diagnosis of ACVS, and imaging positive (either DWI+ or CT/CTA+).
Clinical diagnosis of ACVS, and DWI- and/or CTA-.
Clinical diagnosis of mimic and imaging negative.
This is a non-interventional study. However, several blood samples will be taken which would not be taken as part of standard of care.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
The study population includes individuals presenting to the hospital ED or stroke clinic with symptoms suggesting mild ACVS who would be referred to the outpatient stroke clinic. Patients will be recruited primarily from emergency department settings or hospital-based stroke units.
Foothills Medical Centre
Calgary, Alberta, T2N 2T9, Canada
Vancouver Island Health Authority
Victoria, British Columbia, V8R 1J8, Canada
Penn AM, Croteau NS, Votova K, Sedgwick C, Balshaw RF, Coutts SB, Penn M, Blackwood K, Bibok MB, Saly V, Hegedus J, Yu AYX, Zerna C, Klourfeld E, Lesperance ML. Systolic blood pressure as a predictor of transient ischemic attack/minor stroke in emergency department patients under age 80: a prospective cohort study. BMC Neurol. 2019 Oct 25;19(1):251. doi: 10.1186/s12883-019-1466-4.
Human plasma collected within 24 hours of symptom onset; MRI; Holter +\\- Extended Cardiac Monitoring
Andrew M Penn, M.D.
Vancouver Island Health Authority
Shelagh Coutts, M.D.
Alberta Health services
Christoph Borchers, P.hD
UVic-Genome BC Proteomics Centre
1,150 participants (actual enrollment reported by the registry).
First Submitted
February 28, 2017
First Posted
March 3, 2017
Study Start
April 1, 2015
Actual (reported)Utilization of Ticagrelor in the Upstream Setting for Non-ST-Segment Elevation Myocardial Infarction (UPSTREAM): An ED-Based Clinical Registry
Contact the study team to confirm eligibility.
Primary Completion
March 31, 2017
Actual (reported)Study Completion
March 31, 2017
Actual (reported)Last Updated
August 18, 2017
Record last verified: 2017-08
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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