Reward Processing in Mental Illness

NCT03068793 | Completed

• 1 other identifier: IK2CX001028
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to examine the nature of reward processing dysfunctions in schizophrenia using neuroimaging techniques that capture in vivo brain functioning, such as EEG and fMRI.

Conditions

Early-onset Schizophrenia

Outcome Measures

Primary Outcomes (3)

• EEG

  Electroencephalography, measures signals from the brain while participants conduct specific tasks that measure memory and attention.

  At time of visit

• MRI

  Magnetic Resonance Imaging, measures activity in, and takes detailed pictures of the brain while participants conduct specific tasks that measure memory and attention.

  At time of visit

• Reward Processing Tasks

  A slot machine task where participants can win real money while participating in an EEG and MRI

  At time of visit

Study Arms (5)

Patients with Recent Onset Schizophrenia

Individuals who have been diagnosed with Schizophrenia, Schizoaffective Disorder, or Schizophreniform Disorder within the past five years and meet our research criteria for symptoms indicative of these diseases within the past five years.

Diagnostic Test: Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI)

Patients with Major Depressive Disorder

Individuals who have been diagnosed with Major Depressive Disorder within the past five years and meet our research criteria for symptoms indicative of this disease within the past five years.

Diagnostic Test: Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI)

Patients with Gambling Disorder

Individuals who have been diagnosed with Gambling Disorder within the past five years and meet our research criteria for symptoms indicative of this disease within the past five years.

Diagnostic Test: Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI)

Patients with Post Traumatic Stress Disorder

Individuals who have been diagnosed with Post Traumatic Stress Disorder within the past five years and meet our research criteria for symptoms indicative of this disease within the past five years.

Diagnostic Test: Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI)

Healthy Controls

Individuals who have not met criteria for a psychiatric, mood, or gambling disorder within their lifetime according to our research criteria for symptoms indicative of a psychiatric, mood, or gambling disorder.

Diagnostic Test: Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI)

Interventions

Electroencephalography (EEG) and Magnetic Resonance Imaging (MRI) DIAGNOSTIC_TEST

We will use these techniques combined with tests of reward anticipation and clinical interviews to explore connections between these measures and activity in the brain in patients with a diagnosis of schizophrenia, major depressive disorder, gambling disorder, or post traumatic stress disorder and healthy controls.

Healthy Controls; Patients with Gambling Disorder; Patients with Major Depressive Disorder; Patients with Post Traumatic Stress Disorder; Patients with Recent Onset Schizophrenia

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Patients who have been diagnosed with schizophrenia, schizoaffective disorder, or schizophreniform disorder within the past 5 years and meet our research criteria of symptoms indicative of a diagnosis of schizophrenia within their lifetime are eligible for this study. Patients who have been diagnosed with Major Depressive Disorder, Post Traumatic Stress Disorder, and Gambling Disorder within the past 5 years and meet our research criteria of symptoms indicative of a diagnosis of one of these disorders within their lifetime are also eligible for this study. Healthy controls who have never met criteria for a psychiatric disorder and meet our research criteria will also be included in this study.

You may qualify if:

• The subject population will include 18 to 30 year old participants of any gender, race, and ethnicity. All subjects will be able to speak and understand English.
• Schizophrenia subjects:
• \. Patients must be diagnosed with DSM-IV schizophrenia, schizophreniform, or schizoaffective disorder based on a SCID-P interview.
• Depression subjects:
• \. Patients must be diagnosed with DSM-V Major Depressive Disorder based on a SCID-P interview.
• Post Traumatic Stress Disorder subjects:
• \. Patients must be diagnosed with DSM-V Post Traumatic Stress Disorder based on a SCID-P interview.
• Gambling Disorder subjects:
• \. Patients must be diagnosed with DSM-V Gambling Disorder based on a SCID-P interview.
• Comparison subjects:
• \. Control participants must not have past or present Axis I diagnosis as determined by the SCID-NP.

You may not qualify if:

• All subjects:
• A hearing deficit greater than 40dB in both ears detected during the hearing test
• Substance dependence, as per clinical judgment, in the past 1 year (except caffeine and nicotine)
• A history of significant medical/neurological disease such as cardiac, thyroid, renal, hepatic or neurological
• History of head injury with loss of consciousness greater than 15 minutes
• Any other condition or medication, which in the opinion of the investigator would preclude participation in the study.
• Non-English speaking.
• Comparison subjects:
• \. Any first-degree relative with schizophrenia or bipolar disorder.

Sponsors & Collaborators

• Susanna Fryer: lead

Study Sites (1)

San Francisco VA Medical Center

San Francisco, California, 94121, United States

Location

Related Publications (66)

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MeSH Terms

Interventions

Electroencephalography; Magnetic Resonance Imaging

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Neurological; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis; Tomography; Diagnostic Imaging

Study Officials

• Susanna Fryer, PhD

  San Francisco VA Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: FED
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Professor in Residence

Study Record Dates

• First Submitted: February 27, 2017
• First Posted: March 3, 2017
• Study Start: October 1, 2013
• Primary Completion: June 30, 2019
• Study Completion: June 30, 2019
• Last Updated: July 15, 2019

Record last verified: 2019-07

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)