NCT03068611

Brief Summary

The overall objective of this project is to develop and pilot-test a web-based smoking cessation program that specifically addresses heavy drinking (HD). The project builds upon a well-established, free evidence-based smoking cessation website, BecomeAnEX.org ("EX"), which is supported by Truth Initiative, a national non-profit public health organization, and its research arm, the Schroeder Institute. Investigators will develop an alternative version of BecomenAnEX that will include detailed content on alcohol's relation to smoking relapse, health effects of alcohol (including moderate drinking recommendations) along with related worksheets, feedback materials, and links to resources for drinking. Once a version of BecomeAnEX is developed that specifically addresses HD (called EX-HD), the investigators will conduct a one-arm open pilot of the site with 30 HD smokers recruited from newly registered BecomeAnEX users. The study will gather participant feedback on the site as well as site use metrics (e.g., number of logins, number of pages viewed, use of interactive components) and will revise EX-HD in response to this feedback in preparation for Stage 1b work. Stage 1b will use the updated EX-HD version to run a small scale randomized clinical trial where 120 participants will be randomly assigned to the standard version of BecomeAnEX or to EX-HD.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
119

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started May 2017

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 23, 2017

Completed
8 days until next milestone

First Posted

Study publicly available on registry

March 3, 2017

Completed
2 months until next milestone

Study Start

First participant enrolled

May 11, 2017

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2018

Completed
29 days until next milestone

Study Completion

Last participant's last visit for all outcomes

April 30, 2018

Completed
1.4 years until next milestone

Results Posted

Study results publicly available

October 7, 2019

Completed
Last Updated

October 7, 2019

Status Verified

September 1, 2019

Enrollment Period

11 months

First QC Date

February 23, 2017

Results QC Date

August 23, 2019

Last Update Submit

September 16, 2019

Conditions

Outcome Measures

Primary Outcomes (4)

  • Number of Participants Who Reported 7-day Point-prevalence Smoking Abstinence at 1 Month

    Self-report abstinence from smoking

    1 month after enrollment

  • Number of Participants Who Reported 7-day Point-prevalence Smoking Abstinence at 6 Months

    Self-report abstinence from smoking

    6 months after enrollment

  • Number of Heavy Drinking Days at 1 Month

    Self reported number of days (in the past 30 days) drinking 4+/5+ drinks for women/men

    1 month after enrollment

  • Number of Heavy Drinking Days at 6 Months

    Self reported number of days (in the past 30 days) drinking 4+/5+ drinks for women/men

    6 months after enrollment

Study Arms (2)

Standard Web-based Smoking Cessation

ACTIVE COMPARATOR

A website and text messaging program that is publicly available through BecomeAnEX.com. Participants have access to the website whenever they wish.

Behavioral: Standard Web-based Smoking Cessation

Alcohol-focused Web-Based Smoking Cessation

EXPERIMENTAL

A modified version of the website and text messaging program that is publicly available through BecomeAnEX.com. This version includes specific information and feedback on alcohol use, allows participants to consider benefits of changing drinking, plans for changing drinking, and strategies. Participants have access to the website whenever they wish.

Behavioral: Alcohol-focused Web-Based Smoking Cessation

Interventions

A website and text messaging program that is publicly available through BecomeAnEX.com. Participants have access to the website whenever they wish.

Standard Web-based Smoking Cessation

A website and text messaging program that is publicly available through BecomeAnEX.com. Participants have access to the website whenever they wish.

Alcohol-focused Web-Based Smoking Cessation

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • current daily smoking of at least one cigarette per day
  • meeting NIAAA criteria for past month heavy or at-risk drinking (for women: drinking 8+ drinks per week or consuming 4+ drinks on one occasion at least once in the past month; for men: drinking 15+ drinks per week or consuming 5+ drinks on one occasion at least once in the past month)
  • age 18 or older
  • willingness to provide contact and mailing information following consent

You may not qualify if:

  • \. history of severe alcohol withdrawal as indicated by past alcohol-induced seizures or delirium tremens;

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Center for Alcohol and Addiction Studies, Brown University

Providence, Rhode Island, 02912, United States

Location

Related Publications (1)

  • Kahler CW, Cohn AM, Costantino C, Toll BA, Spillane NS, Graham AL. A Digital Smoking Cessation Program for Heavy Drinkers: Pilot Randomized Controlled Trial. JMIR Form Res. 2020 Jun 8;4(6):e7570. doi: 10.2196/formative.7570.

MeSH Terms

Conditions

Smoking CessationAlcohol Drinking

Interventions

Ethanol

Condition Hierarchy (Ancestors)

Health BehaviorBehaviorDrinking Behavior

Intervention Hierarchy (Ancestors)

AlcoholsOrganic Chemicals

Results Point of Contact

Title
Christopher Kahler
Organization
Brown University

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

February 23, 2017

First Posted

March 3, 2017

Study Start

May 11, 2017

Primary Completion

April 1, 2018

Study Completion

April 30, 2018

Last Updated

October 7, 2019

Results First Posted

October 7, 2019

Record last verified: 2019-09

Data Sharing

IPD Sharing
Will not share

Locations