Muscle Fat Compartments and Turnover as Determinant of Insulin Sensitivity

NCT03065140 | Completed DMC

• 1 other identifier: 16/NS/0024
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

Early research found that high levels of fat within muscle meant poorer control of blood sugar. However, more recent research has shown that athletes have similar levels of fat within muscle, but in contrast, they have very good control of blood sugar. The investigators are not sure why this is and want to find out if the fat within muscle can be changed to improve blood sugar control, as good blood sugar control reduces the risk of heart disease, diabetes and stroke.

Conditions

Diabetes

Outcome Measures

Primary Outcomes (1)

• Non-invasive 1H Magnetic Resonance Spectroscopy of vastus lateralis

  Assessment of energetics of vastus lateralis by MRS

  One Hour

Secondary Outcomes (1)

• Saturated and unsaturated lipid pool turnover examined by stable isotopes

  One hour

Study Arms (2)

Healthy Volunteers

EXPERIMENTAL

Healthy volunteers will undergo the following: * CPEX with/without stable isotope infusion * Muscle biopsies * Magnetic Resonance Spectroscopy Followed by a period of detraining. They will then undergo the following: * CPEX with/without stable isotope infusion * Muscle biopsies * Magnetic Resonance Spectroscopy

Other: Training or detraining

Diabetic Patients

EXPERIMENTAL

Diabetic patients will undergo the following: * CPEX with/without stable isotope infusion * Muscle biopsies * Magnetic Resonance Spectroscopy They will then undergo a supervised training period. They will then undergo the following: * CPEX with/without stable isotope infusion * Muscle biopsies * Magnetic Resonance Spectroscopy

Other: Training or detraining

Interventions

Training or detraining OTHER

A period of detraining or a supervised exercise program.

Also known as: Detraining or training

Diabetic Patients; Healthy Volunteers

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Type 2 diabetic patients, aged between 20-65, diagnosed as per WHO criteria, diet controlled or diet and any of the following oral hypoglycemics: metformin, sulphonylureas, glitazones, gliptins, acarbose, but not requiring insulin for controlling of blood glucose.
• Trained, athletic healthy controls, aged 18 and over.
• Participant who is willing and able to give informed consent for participation in the study.
• Able to perform exercise testing.

You may not qualify if:

• Any history of known coronary artery disease.
• Other endocrine conditions
• Impaired renal function defined as eGFR\<60mls/min/1.73m2
• Known resting/24 hour BP \>160/100mmHg
• Participants on ACE inhibitors
• Participants on PPAR agonists
• Participants on omega 3 fatty acids
• The existence of any medical or surgical condition that in the judgement of the investigators may interfere with the exercise regime, FA metabolism or may compromise the safety of the subject
• Presence of other significant concomitant heart diseases such as ischaemic, valvular, pericardial heart disease or cardiomyopathy, skeletal muscle disorders
• Healthy volunteers that are on any chronic medication that in the judgment of the investigators is likely to affect the outcome of the study
• Significant asthma
• Significant pulmonary disease
• Participants unable to cycle on the ergometer
• Unable to perform exercise testing (e.g. prosthetic limbs)

Sponsors & Collaborators

• University of Aberdeen: lead
• NHS Grampian: collaborator

Study Sites (1)

Cardiac Research Office

Aberdeen, Aberdeenshire, AB25 2ZN, United Kingdom

Location

Related Publications (35)

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  BACKGROUND

MeSH Terms

Conditions

Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Officials

• Dana Dawson, MD

  University of Aberdeen Employee

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 7, 2016
• First Posted: February 27, 2017
• Study Start: September 1, 2016
• Primary Completion: January 1, 2019
• Study Completion: January 1, 2019
• Last Updated: August 31, 2022

Record last verified: 2022-08

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)