Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion
1 other identifier
observational
100
1 country
1
Brief Summary
Retinal vessel occlusions might lead to ischemia of the inner retina, more severe so in artery occlusions. Intracellular edema may develop and decrease transparency of those layers, showing retinal edema. In spectral domain optical coherence tomography (SD-OCT) retinal reflectivity changes as a result of retinal edema. The investigators examine the reflectivity changes of different retinal layers between healthy eyes and eyes with retinal artery occlusion and ischemic or non-ischemic vein occlusions. Aim of the study is to evaluate whether those changes can be used to measure the level of ischemia in the inner retina.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started May 2017
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 19, 2017
CompletedFirst Posted
Study publicly available on registry
February 23, 2017
CompletedStudy Start
First participant enrolled
May 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2023
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2023
CompletedMarch 2, 2023
March 1, 2023
6.6 years
February 19, 2017
March 1, 2023
Conditions
Outcome Measures
Primary Outcomes (1)
reflectivity
optical density of different retinal layers
December 2017
Interventions
measurement of reflectivity in different retinal layers based on optical coherence tomography findings
Eligibility Criteria
Chart Review of patients treated b/o retinal vessel occlusion, who were examined with optical coherence tomography
You may qualify if:
- acute Retinal vessel occlusion on one eye
- healthy contralateral eye
- examined with spectral Domain optical coherence tomography
You may not qualify if:
- retinal occlusion older than 1 week
- OCT Image not obtainable/missing
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Eye Hospital
Dresden, 01307, Germany
Related Publications (1)
Matthe E, Wittig D, Kuhn M, Eulitz P, Schoen K, Sandner D, Furashova O. Manual measurement of SD-OCT images of hyperreflective retinal layers in acute retinal vessel occlusion is reliable, repeatable and reproducible. Sci Rep. 2025 Oct 3;15(1):34471. doi: 10.1038/s41598-025-20086-7.
PMID: 41044164DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Egbert Matthé, MD
Technical University Dresden
Central Study Contacts
Olga Furashova
CONTACT
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
February 19, 2017
First Posted
February 23, 2017
Study Start
May 1, 2017
Primary Completion
December 1, 2023
Study Completion
December 1, 2023
Last Updated
March 2, 2023
Record last verified: 2023-03
Data Sharing
- IPD Sharing
- Will not share