Internet-based Exposure Therapy for Panic Disorder
1 other identifier
interventional
61
1 country
1
Brief Summary
The purpose of this study is examine if an internet-based exposure therapy based on inhibitory learning is feasible, acceptable and effective in reducing panic symptoms amongst patients who suffer from panic disorder and agoraphobia.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Feb 2017
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2017
CompletedFirst Submitted
Initial submission to the registry
February 19, 2017
CompletedFirst Posted
Study publicly available on registry
February 23, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2017
CompletedAugust 22, 2017
August 1, 2017
4 months
February 19, 2017
August 17, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
Panic Disorder Severity Scale - Self rated (PDSS-SR)
Change in panic symptoms from baseline to Week 8
Week 0, Week 8
Secondary Outcomes (12)
Credibility/Expectancy Questionnaire (CEQ)
Week 2
Client Satisfaction Questionnaire (CSQ)
Week 8
Adverse events scale
Week 8
Patient Health Questionnaire (PHQ-9)
Week 0, Week 8
Anxiety Sensitivity Index (ASI)
Week 0, Week 8
- +7 more secondary outcomes
Study Arms (2)
Inhibitory learning based treatment
EXPERIMENTALThe experimental group will go through Internet-based treatment. The exposure treatment is 8 weeks long and based on the principles of inhibitory learning, i.e. the participant is instructed to stay in the frightening situation until his/her expectancy has been maximally violated.
Habituation based treatment
ACTIVE COMPARATORThe active comparator group will also go through Internet-based treatment. The exposure treatment is 8 weeks long and based on the principles of emotional processing theory, i.e. the participant is instructed to stay in the frightening situation until anxiety has declined (habituated).
Interventions
Internet-based cognitive-behavior therapy on a safe internet platform. Treatment is divided into eight modules, each containing homework assignments . The participants will be assigned a therapist that they can contact through a message system in the platform and expect answer within 24 hours.
Eligibility Criteria
You may qualify if:
- Outpatients
- ≥ 18 years
- Situated in Sweden
- Informed consent
- Panic Disorder Severity Scale - self rated score more than 6 points
You may not qualify if:
- Substance dependence during the last six months
- Post traumatic stress disorder, bipolar disorder or psychosis
- Symptoms better explained by axis 2 diagnosis (e.g. autism or borderline personality disorder)
- MADRS-S score above 25 points
- Psychotropic medication changes within one months prior to treatment that could affect target symptoms.
- Received exposure based Cognitive behavior therapy (CBT) for pathological worry the last 2 years
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Karolinska Institutet
Stockholm, 17177, Sweden
Study Officials
- PRINCIPAL INVESTIGATOR
Erik M Andersson, PhD
Karolinska Institutet
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PhD, psychologist
Study Record Dates
First Submitted
February 19, 2017
First Posted
February 23, 2017
Study Start
February 1, 2017
Primary Completion
June 1, 2017
Study Completion
June 1, 2017
Last Updated
August 22, 2017
Record last verified: 2017-08