NCT03060941

Brief Summary

A randomized multi-component physical activity intervention for breast cancer survivors.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
355

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Dec 2017

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

February 17, 2017

Completed
6 days until next milestone

First Posted

Study publicly available on registry

February 23, 2017

Completed
9 months until next milestone

Study Start

First participant enrolled

December 4, 2017

Completed
2.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 28, 2020

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 28, 2020

Completed
Last Updated

January 26, 2021

Status Verified

January 1, 2021

Enrollment Period

2.2 years

First QC Date

February 17, 2017

Last Update Submit

January 23, 2021

Conditions

Outcome Measures

Primary Outcomes (1)

  • Moderate-to-vigorous physical activity measured by Actigraph accelerometer

    Measure physical activity at baseline and follow-up periods (3- and 6-months post-baseline) and assess percentage of survivors meeting physical activity guideline recommendations.

    24 weeks

Study Arms (16)

Group 1

EXPERIMENTAL

Physical activity education

Behavioral: Physical activity education

Group 2

EXPERIMENTAL

Physical activity education and facility access

Behavioral: Physical activity educationBehavioral: Facility access

Group 3

EXPERIMENTAL

Physical activity education and supervised exercise sessions

Behavioral: Physical activity educationBehavioral: Supervised exercise sessions

Group 4

EXPERIMENTAL

Physical activity education and self-monitoring (Fitbit)

Behavioral: Physical activity educationBehavioral: Self-monitoring (Fitbit)

Group 5

EXPERIMENTAL

Physical activity education and active living counseling

Behavioral: Physical activity educationBehavioral: Active living counseling

Group 6

EXPERIMENTAL

Physical activity education, facility access, and supervised exercise sessions

Behavioral: Physical activity educationBehavioral: Facility accessBehavioral: Supervised exercise sessions

Group 7

EXPERIMENTAL

Physical activity education, facility access, and self-monitoring (Fitbit)

Behavioral: Physical activity educationBehavioral: Facility accessBehavioral: Self-monitoring (Fitbit)

Group 8

EXPERIMENTAL

Physical activity education, facility access, and active living counseling

Behavioral: Physical activity educationBehavioral: Facility accessBehavioral: Active living counseling

Group 9

EXPERIMENTAL

Physical activity education, supervised exercise sessions, and self-monitoring (Fitbit)

Behavioral: Physical activity educationBehavioral: Supervised exercise sessionsBehavioral: Self-monitoring (Fitbit)

Group 10

EXPERIMENTAL

Physical activity education, supervised exercise sessions, and active living counseling

Behavioral: Physical activity educationBehavioral: Supervised exercise sessionsBehavioral: Active living counseling

Group 11

EXPERIMENTAL

Physical activity education, self-monitoring (Fitbit), and active living counseling

Behavioral: Physical activity educationBehavioral: Self-monitoring (Fitbit)Behavioral: Active living counseling

Group 12

EXPERIMENTAL

Physical activity education, facility access, supervised exercise sessions, and self-monitoring (Fitbit)

Behavioral: Physical activity educationBehavioral: Facility accessBehavioral: Supervised exercise sessionsBehavioral: Self-monitoring (Fitbit)

Group 13

EXPERIMENTAL

Physical activity education, facility access, supervised exercise sessions, and active living counseling

Behavioral: Physical activity educationBehavioral: Facility accessBehavioral: Supervised exercise sessionsBehavioral: Active living counseling

Group 14

EXPERIMENTAL

Physical activity education, facility access, self-monitoring (Fitbit), and active living counseling

Behavioral: Physical activity educationBehavioral: Facility accessBehavioral: Self-monitoring (Fitbit)Behavioral: Active living counseling

Group 15

EXPERIMENTAL

Physical activity education, supervised exercise sessions, self-monitoring (Fitbit), and active living counseling

Behavioral: Physical activity educationBehavioral: Supervised exercise sessionsBehavioral: Self-monitoring (Fitbit)Behavioral: Active living counseling

Group 16

EXPERIMENTAL

Physical activity education, facility access, supervised exercise sessions, self-monitoring (Fitbit), and active living counseling

Behavioral: Physical activity educationBehavioral: Facility accessBehavioral: Supervised exercise sessionsBehavioral: Self-monitoring (Fitbit)Behavioral: Active living counseling

Interventions

Participants will be given educational materials on how to increase physical activity levels.

Group 1Group 10Group 11Group 12Group 13Group 14Group 15Group 16Group 2Group 3Group 4Group 5Group 6Group 7Group 8Group 9
Facility accessBEHAVIORAL

Participants will receive at 6 month membership to a local fitness facility.

Group 12Group 13Group 14Group 16Group 2Group 6Group 7Group 8

Participants will attend weekly supervised exercise sessions with an exercise interventionist.

Group 10Group 12Group 13Group 15Group 16Group 3Group 6Group 9

Participants will be given a Fitbit to monitor their physical activity levels.

Group 11Group 12Group 14Group 15Group 16Group 4Group 7Group 9

Participants will attend 12 biweekly educational sessions about how to increase their physical activity levels.

Group 10Group 11Group 13Group 14Group 15Group 16Group 5Group 8

Eligibility Criteria

Age18 Years+
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • breast cancer survivors between 3 months and 5 years post-treatment
  • report \<150 minutes of moderate-to-vigorous physical activity (MVPA) on the GPAQ
  • physically able to engage in physical activity

You may not qualify if:

  • medical condition contraindicating physical activity participation
  • cognitively unable to give informed consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

UT Southwestern Medical Center

Dallas, Texas, 75235, United States

Location

Related Publications (2)

  • Rethorst CD, Carmody TJ, Argenbright KE, Mayes TL, Hamann HA, Trivedi MH. Considering depression as a secondary outcome in the optimization of physical activity interventions for breast cancer survivors in the PACES trial: a factorial randomized controlled trial. Int J Behav Nutr Phys Act. 2023 Apr 20;20(1):47. doi: 10.1186/s12966-023-01437-x.

  • Rethorst CD, Hamann HA, Carmody TJ, Sharp KJ, Argenbright KE, Haley BB, Skinner CS, Trivedi MH. The Promoting Activity in Cancer Survivors (PACES) trial: a multiphase optimization of strategy approach to increasing physical activity in breast cancer survivors. BMC Cancer. 2018 Jul 18;18(1):744. doi: 10.1186/s12885-018-4662-5.

MeSH Terms

Conditions

Motor ActivityBreast Neoplasms

Interventions

Architectural Accessibility

Condition Hierarchy (Ancestors)

BehaviorNeoplasms by SiteNeoplasmsBreast DiseasesSkin DiseasesSkin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

Facility Design and ConstructionArchitectureTechnology, Industry, and Agriculture

Study Officials

  • Madhukar H Trivedi, MD

    UTSW

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: The 500 participants in the physical activity intervention will be randomly assigned to one of sixteen intervention groups (see Table below). Randomization will be stratified by clinical site. The randomization scheme will be conducted by the study statistician. The randomization scheme will consist of balanced blocks within each stratum, with block size will be varied and randomly permuted. Allocation will occur following completion of baseline assessments.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
PROFESSOR

Study Record Dates

First Submitted

February 17, 2017

First Posted

February 23, 2017

Study Start

December 4, 2017

Primary Completion

February 28, 2020

Study Completion

February 28, 2020

Last Updated

January 26, 2021

Record last verified: 2021-01

Data Sharing

IPD Sharing
Will not share

Locations