NCT03060603|Completed
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Sponsor study identifier
observational
14
1 country
1
Study Start
February 23, 2017
Actual (reported)Primary Completion
December 29, 2017
Actual (reported)Study Completion
January 15, 2018
Actual (reported)The purpose of this study to assess the proliferative effects of erythropoetin on human endometrium tissue by measuring the endometrial thickness, uterine artery and subendometrial blood flow in postmenopausal women.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
January 15, 2018
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
February 10, 2017
Actual (reported)February 23, 2017
Actual (reported)February 23, 2017
Actual (reported)December 29, 2017
Actual (reported)January 15, 2018
Actual (reported)Change from Baseline Endometrial Thickness Confirmed by Transvaginal Ultrasonography at 3th and 30th Days
Change from Baseline Endometrial Thickness Confirmed by Transvaginal
within the first 3 and 30 days (plus or minus 3 days) after the erythropoietin treatment
Recombinant Human Erythropoietin, EPREX 4000 IU/0.4 ml, three times in a week, until the correction of anemia, approximately two months.
Recombinant Human Erythropoietin, three times in a week, until the correction of anemia, approximately two months.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Patients will be recruited from a tertiary research clinic, department of nephrology, Istanbul, Turkey.
Fatih Sultan Mehmet Training and Research Hospital
Istanbul, Atasehir, 34758, Turkey (Türkiye)
Tug N, Altunkaynak ME, Aktas RG, Kilic U, Yilmaz B, Cam C, Karateke A. Does erythropoietin affect motility of spermatozoa? Arch Gynecol Obstet. 2010 May;281(5):933-8. doi: 10.1007/s00404-009-1289-4. Epub 2009 Nov 25.
Tug N, Kilic U, Karateke A, Yilmaz B, Ugur M, Kilic E. Erythropoietin receptor-like immunostaining on human spermatozoa. Reprod Biomed Online. 2010 Nov;21(5):718-20. doi: 10.1016/j.rbmo.2010.05.022. Epub 2010 Jun 19.
Niyazi Tug, Ass.Prof.
Executive and Educational Supervisor
14 participants (actual enrollment reported by the registry).
First Submitted
February 10, 2017
First Posted
February 23, 2017
Study Start
February 23, 2017
Actual (reported)Asses the Impact of Early Starting Erythropoetin in the Reduction of Transfusions Blood in Childrens
Contact the study team to confirm eligibility.
Wang L, Di L, Noguchi CT. Erythropoietin, a novel versatile player regulating energy metabolism beyond the erythroid system. Int J Biol Sci. 2014 Aug 23;10(8):921-39. doi: 10.7150/ijbs.9518. eCollection 2014.
Ogilvie M, Yu X, Nicolas-Metral V, Pulido SM, Liu C, Ruegg UT, Noguchi CT. Erythropoietin stimulates proliferation and interferes with differentiation of myoblasts. J Biol Chem. 2000 Dec 15;275(50):39754-61. doi: 10.1074/jbc.M004999200.
Yokomizo R, Matsuzaki S, Uehara S, Murakami T, Yaegashi N, Okamura K. Erythropoietin and erythropoietin receptor expression in human endometrium throughout the menstrual cycle. Mol Hum Reprod. 2002 May;8(5):441-6. doi: 10.1093/molehr/8.5.441.
Yasuda Y, Masuda S, Chikuma M, Inoue K, Nagao M, Sasaki R. Estrogen-dependent production of erythropoietin in uterus and its implication in uterine angiogenesis. J Biol Chem. 1998 Sep 25;273(39):25381-7. doi: 10.1074/jbc.273.39.25381.
Primary Completion
December 29, 2017
Actual (reported)Study Completion
January 15, 2018
Actual (reported)Last Updated
January 23, 2018
Record last verified: 2018-01
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Source: ClinicalTrials.gov.
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