Spectrometry for TIA Rapid Assessment (SpecTRA) Project: Study 1 Cohort 1A and 1B-Verification of Protein Biomarkers
Sponsor study identifier
observational
560
1 country
2
Study Start
December 1, 2013
Actual (reported)Primary Completion
June 30, 2015
Actual (reported)Study Completion
December 31, 2016
Actual (reported)A multi-protein test using mass spectrometry (MS) for multiplexed protein quantitation is being developed. This test and the accompanying decision-aid software will provide Transient Ischemic Attack (TIA) results rapidly for a fraction of the price of neuroimaging. With guidance provided by this test, Emergency Department (ED) physicians can manage medical imaging questions such as the use of Computed Tomography Angiography (CTA) prior to ED discharge and appropriate (timely) referral to stroke clinics for consultation and follow-up care. The right patients will receive the right treatment, reduce unwarranted imaging risks and costs, and reduce the burden of stroke.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2016
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
December 1, 2013
Actual (reported)June 30, 2015
Actual (reported)December 31, 2016
Actual (reported)February 8, 2017
Actual (reported)February 10, 2017
Actual (reported)The Development of a Protein Classifier for the Diagnosis of TIA in the Emergency Department.
141 proteins measured using multiple reaction monitoring mass spectrometry. Proteins were selected due to previous implication in stroke, TIA, migraine, other conditions that can be confused with ACVS, and other cardiovascular disturbances.
24 Hours
The Development of a Clinical Classifier for the Diagnosis of TIA in the Emergency Department.
24 Hours
Clinical diagnosis of ACVS, and imaging positive (either DWI+ or CT/CTA+).
Clinical diagnosis of ACVS, and DWI- and/or CTA-
Clinical diagnosis of mimic and imaging negative.
This is a non-interventional study. However, several blood samples will be taken which would not be taken as part of standard of care.
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
All patients presenting to the hospital Emergency Department with symptoms suggesting mild ACVS and who are referred to the stroke service or TIA rapid access clinic by the emergency room physician.
Foothills Medical Centre
Calgary, Alberta, T2N 2T9, Canada
Vancouver Island Health Authority
Victoria, British Columbia, V8R 1J8, Canada
Penn AM, Lu L, Chambers AG, Balshaw RF, Morrison JL, Votova K, Wood E, Smith DS, Lesperance M, del Zoppo GJ, Borchers CH; SpecTRA Study Group. Exploring phlebotomy technique as a pre-analytical factor in proteomic analyses by mass spectrometry. Genome. 2015 Dec;58(12):569-76. doi: 10.1139/gen-2015-0036. Epub 2015 Jul 10.
Penn AM, Croteau NS, Votova K, Sedgwick C, Balshaw RF, Coutts SB, Penn M, Blackwood K, Bibok MB, Saly V, Hegedus J, Yu AYX, Zerna C, Klourfeld E, Lesperance ML. Systolic blood pressure as a predictor of transient ischemic attack/minor stroke in emergency department patients under age 80: a prospective cohort study. BMC Neurol. 2019 Oct 25;19(1):251. doi: 10.1186/s12883-019-1466-4.
Human plasma collected within 24 hours of symptom onset; MRI; Holter +/- Extended Cardiac Monitoring
Andrew M Penn, M.D
Vancouver Island Health Authority
Shelagh Coutts, M.D.
Alberta Health services
Christoph Borchers, P.hD
UVic- Genome BC Proteomics Centre
560 participants (actual enrollment reported by the registry).
First Submitted
February 8, 2017
First Posted
February 10, 2017
Study Start
December 1, 2013
Actual (reported)Formation of Antibodies and Subsequent Prediction of Clinical Response in Patients With Rheumatoid Arthritis Treated With Four TNF Blocking Agents
Contact the study team to confirm eligibility.
Primary Completion
June 30, 2015
Actual (reported)Study Completion
December 31, 2016
Actual (reported)Last Updated
March 3, 2017
Record last verified: 2017-02
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Source: ClinicalTrials.gov.
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