Study of Arterial Recanalization of the Central Retinal Artery Occlusions
RECANAL
1 other identifier
observational
80
1 country
1
Brief Summary
Central retinal artery occlusions (CRAO) are the equivalent of an ischemic stroke (IS) at the retinal level. They share the same risk factors and common pathology. Their incidence is lower (8.5 / 100,000) and the functional prognosis is unfavorable in 80% of cases with visual acuity (VA) \<1/10. The diagnosis of an CRAO is clinically based on the sudden occurrence of a decrease in deep visual acuity with fundamentally signs of reactive ischemia. There is no data on early retinal arterial recanalization after CRAO, nor on the relationship between early recanalization (spontaneous or post-thrombolysis) and visual prognosis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Dec 2016
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 23, 2016
CompletedFirst Submitted
Initial submission to the registry
February 8, 2017
CompletedFirst Posted
Study publicly available on registry
February 10, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 2, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
April 2, 2022
CompletedApril 14, 2022
April 1, 2022
5.3 years
February 8, 2017
April 7, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Dynamic retinal angiography data at 24 hours (+/- 24 hours)
Proportion of patients with early arterial recanalization.The recanalization rate will be compared between thrombolysed patients and non-thrombolysed patients
24 hours (+/- 24 hours) following the beginning of symptoms
Eligibility Criteria
Patients referred for an central retinal artery occlusion
You may qualify if:
- Central Retinal Artery Occlusion ≤ 24 hours
You may not qualify if:
- Retinal Dynamic angiography not performed within 48 hours of onset of symptoms
- Occlusion of a branch of the central retinal artery
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Fondation ophtalmique Adolphe de Rothschild
Paris, 75019, France
Related Publications (1)
Abdelmassih Y, Mauget-Faysse M, Seners P, Milea D, Hallali G, Guillaume J, Lecler A, Vignal C, Le Mer Y, Paques M, Bonnin S, Obadia M. Early reperfusion in patients with acute retinal artery occlusion: A multicenter prospective study. Int J Stroke. 2025 Mar;20(3):338-346. doi: 10.1177/17474930241306692. Epub 2024 Dec 24.
PMID: 39614619DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Michaël Obadia, MD
Fondation A de Rothschild
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- NETWORK
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 8, 2017
First Posted
February 10, 2017
Study Start
December 23, 2016
Primary Completion
April 2, 2022
Study Completion
April 2, 2022
Last Updated
April 14, 2022
Record last verified: 2022-04